Figure 1
From: Non-apoptotic functions of caspase-7 during osteogenesis
Localisation of activated caspase-7 and osteocalcin in mandibular and alveolar bones at embryonic and postnatal stages. Morphology of mandible visualised by haematoxylin-eosin staining at ED13.5 (a), ED15.5 (b), ED17.5 (c), and P5 (d). Localisation of activated (cleaved) caspase-7 in cells of mandibular bone at ED13.5 (e and f), ED15.5 (g and h), ED17.5 (i–k), and alveolar bone at P5 (l and m). Expression of osteocalcin in cells of mandibular bone at ED13.5 (n and o), ED15.5 (p and q), ED17.5 (r and s), and alveolar bone at P5 (t and u). Arrows point to the positive cells (brown); alv (alveolar bone), C7 (caspase-7), I (incisor), M1 (first molar), mand (mandibular bone), mec (Meckel’s cartilage), and OS (osteocalcin). Scale bar=100 μm in figures: a, b, c, d, e, g, i, j, l, n, p, r, t; scale bar=50 μm in figures: f, h, k, m, o, q, s, u
