Figure 2 | Cell Death & Disease

Figure 2

From: Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors

Figure 2

Increased Gal-3 expression and nuclear localization are induced by RA. (a) Phase contrast microphotographs documenting the morphological differentiation and the induction of neurites by RA on the N-type SK-N-BE(2)c and LAN-5 NB cell lines. Along with this effect, RA also induced the well-known downregulation of MYCN, and a dose dependent (b) Gal-3 increase at the mRNA and protein level as evidenced by Q-PCR (c, upper panel) and immunoblotting (c, lower panel), respectively, in both N-type NB cell lines. (d) Immunofluorescence analysis of Gal-3 expression on fixed SK-N-BE(2)c and LAN-5 cells showed that RA treatment promoted Gal-3 localization to the cell nucleus

Back to article page