Figure 3
From: The emerging role of Toll-like receptor 4 in myocardial inflammation
Negative regulation of TLR4 signaling pathways. The TLR4 antagonist eritoran inhibits TLR4 recognition of LPS. SHIP-1 inhibits the interaction between TLR4 and MyD88. ST2 sequesters MAL and MyD88. MyD88s can block the association between IRAK4 and MyD88. TOLLIP and SOCS1 can associate with IRAK1 and inhibit its activity. IRAKM inhibits the dissociation of IRAKs from MyD88 and prevents the formation of the IRAKs-TRAF6 complex. SIGIRR negatively regulates TLR4 signaling pathways by interacting transiently with TLR4, IRAK4, and TRAF6. TRIM30α destabilizes the TAK1 complex by promoting the degradation of TAB2 and TAB3. SARM specifically blocks the MyD88-independent signaling. miR-146 targets TRAF6 and IRAK1 and thus negatively regulates TLR4 signaling pathways. In addition, miR-155 can target SHIP-1 and thus suppress the negative regulation on TLR4 signaling pathways. Gene names: MAL, MyD88-adapter like; miR, microRNA; MyD88s, MyD88 short; SARM, Sterile α- and armadillo-motif-containing protein; SHIP-1, Src homology 2 domain-containing inositol 5-phosphatase 1; SOCS1, suppressor of cytokine signaling 1; ST2, suppression of tumorigenicity 2; TOLLIP, Toll-interacting protein
