Figure 5 | Cell Death & Disease

Figure 5

From: Immunoproteomic identification and characterization of Ni2+-regulated proteins implicates Ni2+ in the induction of monocyte cell death

Figure 5

Confocal scanning microscopy analysis of Ni2+-induced apoptotic cell death in human monocytes. Control and Ni2+-stimulated cells (250 μM) were stained by Phalloidin Alexa Fluor 546 (Phalloidin 546) and DAPI (a–f). Confocal z-stack images from Phalloidin- and DAPI-stained monocyte sections (a–c) demonstrated direct Ni2+ effect on cytoskeleton (b–e), if compared with control (a). Apoptosis was induced by 250 μM NiSO4 as shown by 3D images (Imaris software) of chromatin condensation and segregation of the nucleus (c, d, and f)

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