Figure 5 | Cell Death & Disease

Figure 5

From: DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway

Figure 5

DCZ3301 regulates the signaling pathways of Akt, ERK 1/2 and STAT3. (a) OCI-LY8 and NU-DUL-1 cells were treated with the indicated concentrations of DCZ3301 (8 and 16 μM) for 48 h. Western blotting analysis was performed to examine the protein levels of Akt, phospho-Akt, ERK1/2, phospho-ERK1/2, janus kinase 2 (JAK2), phospho-JAK2, STAT3, phospho-STAT3, c-Myc and Actin. (b) OCI-LY8 and NU-DUL-1 cells were both transfected with STAT3 siRNA and negative-control siRNA, respectively. The protein levels of STAT3 and Actin were analyzed by western blotting. (c) The transfected DLBCL cells were treated with 4 and 8 μM DCZ3301 for 48 h, following cell proliferation assessment using CCK-8

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