Figure 3 | Cell Death & Disease

Figure 3

From: The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury

Figure 3The alternative text for this image may have been generated using AI.

CXCL1, CXCL2 and CXCR2 interaction mediates the recruitment of MDSCs in injured kidney. (a) The expression of chemokine CXCL1, CXCL2 mRNA in kidney were upregulated on POD 1 and POD 2, but the expression of CXCL3 and CXCL7 mRNA were not (the expression was normalized to GAPDH and relative to control). (b) The percentage of CD11b+CXCR2+ cells in the kidney on POD 1 and POD 2 were increased in the rapamycin-treated group compared with sham group and the IR group. Cells in the kidney were gated first in FSC/SSC, and then CD11b+CXCR2+ cells were detected by flow cytometry. (data were shown as mean±S.D.; n=5 mice per group per time point; POD, postoperative day)

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