Figure 1
From: Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells
Vitamin D3 analog MC903 induces AD. (a) Schematic of MC903 application. (b) Increase in ear thickness after daily MC903 treatment. (c and d) Photographs (c) and H&E staining (d) of MC903- and ethanol-treated ears at day 12. Scale bar represents 50 μm. (e) The infiltrating CD11b+ and CD11b+ Ly6G+ cells in skin of AD lesions by FACS. (f-n) The expression of MPO (f), LCN-2 (g), MMP-9 (h), IL-4 (i), IL-13 (j), IL-5 (k), eotaxin-2 (l) and TSLP (m and n) in the ear treated with ethanol or MC903. *P<0.05,**P<0.01,***P<0.001. P-values were analyzed by one-way ANOVA in b and m, two-tailed t-tests in e or two-way ANOVA in f-l and n. All data are representative of two to three independent experiments with n=5 per group and are means±S.E.M.
