Figure 6
From: TRAIP regulates replication fork recovery and progression via PCNA
Working model depicting how TRAIP participates in regulating PCNA unloading from stressed replication forks. PCNA is dynamically loaded and unloaded at replication forks in proliferating cells (a). TRAIP senses nucleotide shortage and translocates to stressed replication forks where it promotes PCNA unloading via an undefined mechanism (b). In the absence of TRAIP, PCNA turnover from chromatin is perturbed and DNA synthesis is compromised (c).
