Figure 1 | Cancer Gene Therapy

Figure 1

From: Tetracycline-inducible promoter-based conditionally replicative adenoviruses for the control of viral replication

Figure 1

Scheme of tetracycline-inducible CRAd system. The replication of the CRAd and AdTRE-E1 is under the control of a tetracycline-inducible promoter containing the tetracycline-responsive element (TRE). The recombinant transactivator protein is supplied from AdCMV-rtTA. After the conformational change with tetracycline, the transactivator protein provides binding activity to TRE, and activates the promoter transcriptionally. Then, the expressed E1A protein triggers the replications of the AdTRE-E1 and AdCMV-rtTA genomes. Without tetracycline, the transactivator protein remains inactive and the viruses cannot replicate. In this system, tetracycline functions as a switch for viral replication.

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