Figure 1 | Cellular & Molecular Immunology

Figure 1

From: Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

Figure 1

Adoptive transfer of antigen-specific T cells induces acute hepatitis. (a) Analysis of ALT activity in Ova × CreERT2 mouse plasma on the indicated days upon adoptive transfer of 5 × 106 naı¨ve OT-I cells. ALT activity below 40 U L−1 was considered to be physiological. (b) qRT-PCR-based analysis of Ova expression within the liver of Ova × CreERT2 mice on day 13 upon adoptive transfer of OT-I cells. The means of n ≥ 4 mice/group ± SD are shown. The kinetic analysis was performed twice, analysis of day 3 was done more than 6 times.

Back to article page