Figure 4 | Cellular & Molecular Immunology

Figure 4

From: Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

Figure 4

The capacity of OT-I cells primed inflow antigen conditions and subsequently exposed to high antigen loads. (a) The experimental scheme. (b) Serum ALT levels upon adoptive transfer of 5 × 106 naı¨ve OT-I cells into low antigen-expressing mice on days -10 and 3 upon induction of a high antigen load. The intrahepatic Ova expression levels were assessed with qRT-PCR 14 days following Tam application (c). At the same time, the numbers of Thy1.1+ OT-I cells in the liver (left panel) and spleen (right panel) were calculated (d). Mean of n ≥ 3 mice/group ± SD is shown for one of two independent experiments.

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