Abstract
zpl (zip-like) gene mutant embryos showed the cuticular defect with alternative denticle rows and a hole from head to abdomen. zpl mutants also caused the overgrowth of neural cells and axons both in CNS and PNS as well as the wrong pathway of neural fasciculation and the disappearance of hypophysis, as shown by whole mount embryos stained with antibody against HRP and MAb-22C10. Genetic analysis has provided evidence that zpl, located in the right arm of the second chromosome (between 75 and 102 genetic map units), is a new gene closely related to the zip gene.
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Acknowledgements
We would like to thank our colleagues in Dr. H. Jaeckle's laboratory for many stimulating discussions during the course of the work, Dr. Nusslein-Volhard C. for the use of zip mutant flies and Dr. A. Ferrus for the gift of monoclonal antibodies. Special thanks to Dr. W. Hennig for critical reading and comments on the manuscript. D. Zhao was supported by the Ministry of Education of China, and by a Max-Planck-Society Fellowship. The work was supported by a DFG grant(Leibniz-programm) and SJLLS.
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* The main part of work reported here was finished in Max-Planck-Institute of Developmental Biology, Spemannstr. 35, D-7400 Tubingen, Germany.
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Zhao, D., Cote, S., Jurgens, G. et al. zpl, a new gene in drosophila required for neurogenesis. Cell Res 4, 117–125 (1994). https://doi.org/10.1038/cr.1994.12
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DOI: https://doi.org/10.1038/cr.1994.12
