Table 2 Role of Ca2+ in the etiology of SCA

From: m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration

Type of SCA

Protein

Effect on Ca2+ homeostasis

References

SCA1

Ataxin 1

Reduction of PC Ca2+-binding protein levels

79, 80

SCA2

Ataxin 2

Increase Ca2+ release from ER stores

81, 82

SCA3

Ataxin 3

Increase Ca2+ release from ER stores

83

SCA5

β-III-spectrin

Increase

84

SCA6

CACNA1A

Impaired Ca2+ flux into neurons

85

SCA14

PKCγ

Increase/Decrease

86

SCA15

ITPR1

Inositol 1,4,5-triphosphate Ca2+ signaling

87

SCA28

AFG3-like protein 2

MCU complex assembly

47

  1. CACNA1A, Ca2+ voltage-gated channel subunit alpha1 A; PKCγ, protein kinase C subunit γ; ITPR1, inositol 1,4,5-trisphosphate receptor type 1; SCA, spinocerebellar ataxias.
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