Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The cyclin-dependent kinase (CDK) family is a group of 21 kinases involved in transcription and cell cycle regulation. The CDKs are unique among the human kinases in their requirement of a cyclin partner protein to form an active enzyme complex. Several members of the family are established as oncology drug targets, with inhibitors of CDK4/6 on the market and inhibitors of CDK1, 2, 5, 7 and 9 in clinical trials.
Enjoying our latest content?
Log in or create an account to continue
Access the most recent journalism from Nature's award-winning team
Explore the latest features & opinion covering groundbreaking research
This article is part of a series from the NIH Common Fund Illuminating the Druggable Genome (IDG) programme. The goal of IDG is to catalyse research on understudied proteins from druggable gene families by providing reagents, phenotypes and a mineable database, focusing on G protein-coupled receptors, kinases and ion channels. For more information, see https://druggablegenome.net/
Unexplored therapeutic opportunities in the human genome
