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Micrograph of neuroepithelial embryonic stem cells arranged into flower-like shapes

Credit: Sumana Shrestha

Brain-cell bouquet captures imaging prize

This image — captured using confocal microscopy — shows embryonic stem cells that are destined to become brain cells. The cells arrange themselves into flower-like rings or ‘neural rosettes’ — with columns protruding outwards. In a developing embryo, these structures ultimately go on to generate the brain and spinal cord. Sumana Shrestha, a PhD student at the Institute of Cancer Research in London, took the image — which was selected as the supporters’ favourite at the ICR’s annual science and medical imaging competition. Rosettes are involved in the development of some brain tumours, and understanding them could pave the way for new brain cancer drugs.

See more of the month’s sharpest science shots, selected by Nature’s photo team.

Nature | Leisurely scroll

Your guide to Plan S

Plan S, the open-access initiative shaking up science publishing by removing journal paywalls, officially started this year. Discover what the initiative means for scientists and journals — and some of the controversies that will play out in 2021 and beyond.

Nature | 8 min read

Ant portraits put a spotlight on tiny marvels

A new collection of photographs illustrates the striking diversity of ants — from the inquisitive gaze of West Africa’s Dorylus mayri to the spiky armour of the Daceton armigerum in South America. We share our world with at least 15,000 species of ants. Whole ecosystems are built around these insects, and many species, from plants to beetles to birds, are “ant obligates” whose survival depends entirely on their relationships with ant colonies. The portraits by photographer Eduard Florin Niga take an intimate look at the often overlooked complexity of these tiny marvels. “To answer the question posed by an ant’s form is to begin to untangle the intricate relationships that scaffold our world,” writes entomologist Eleanor Spicer Rice.

New York Times | 7 min read

COVID-19 coronavirus update

What might link vaccine and blood clots

On Wednesday, the European Medicines Agency (EMA) concluded that the Oxford–AstraZeneca COVID-19 vaccine is possibly linked to very rare blood clots accompanied by low levels of blood platelets. The finding leaves researchers wrestling with a medical mystery. The combination of clots and low platelets is counterintuitive because platelets normally promote clotting. The clots also appeared in unusual places, such as the brain and abdomen, rather than the legs, where most deep-vein blood clots form. Some investigations are looking at whether the side effect is a form of the similar phenomenon heparin-induced thrombocytopenia (HIT), a rare side effect of the blood-thinning drug heparin. Much more research is needed before answers will be found. In the meantime, the EMA and physicians emphasize that the benefits of the Oxford–AstraZeneca vaccine still outweigh its risks.

Nature | 6 min read

Understanding vaccine risk

“The risk of mortality from COVID is much greater than the risk of mortality from these side effects,” said EMA executive director Emer Cooke during Wednesday’s announcement. But humans are notoriously bad at weighing risks. The Winton Centre for Risk and Evidence Communication at the University of Cambridge has put together a handy group of charts to clarify things. The graphics compare the risk of ending up in intensive care with COVID-19 with the risk of a blood clot possibly linked to the vaccine. They show that, even when COVID-19 case rates are fairly low, the potential benefit of being vaccinated far outweighs the potential harm. And that’s not even considering the risk of COVID-19 leading to non-intensive-care hospitalization or long-term symptoms — or the benefit of vaccinated people not infecting others.

Winton Centre for Risk and Evidence Communication | 4 min read

Coronapod: Very rare vaccine side effects

From blood clots to allergic reactions, it is fiendishly challenging to prove that an ‘adverse event’ following immunization was caused by the vaccine itself. The Nature Coronapod podcast explores why it is so hard to investigate the rare side effects of COVID vaccines, and how better surveillance systems that collect adverse-event data might help.

Nature Coronapod | 13 min listen

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Features & opinion

Tell us if we’re arguing with a machine

As artificial intelligence (AI) systems become better at framing persuasive arguments, should it always be made clear whether you’re engaging in discourse with a human or a machine? A Nature editorial argues that a debate-winning AI highlights the need for more transparency to avoid manipulation and harm.

Nature | 6 min read

Futures: Made out of muscle and oil

Author Douglas DiCicco considers the debt-bondage systems immortalized in the classic song ‘Sixteen Tons’ in the latest short story for Nature’s Futures series. “In a future where employment requires not only specialized equipment but specialized bodies, it is all too easy to see how this particular form of exploitation could resurface,” says DiCicco.

Nature | 4 min read

Five best science books this week

Andrew Robinson’s pick of the top five science books to read this week includes a physicist taking on academic racism; green economic growth; and Stephen Hawking’s self-promotion.

Nature | 3 min read

Where I work

Engineer Sofia Polo taking water samples while in a canoe

Sofia Polo is an engineer with the Gothenburg department of sustainable waste and water in Sweden.Credit: Jim De Block for Nature

“This storm-water pond, which collects runoff from nearby Gothenburg, is part of a larger effort to help the Swedish city live up to its billing as the ‘Greenest City on Earth’,” says engineer Sofia Polo. But despite the bucolic appearance, “it’s not a wilderness experience”, she says. The pond is near a main road, and its role is to filter out heavy pollutants before water reaches the sea. (Nature | 3 min read)