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What the Omicron wave is revealing about human immunity

Immunologists have raced to work out how to protect against multiple variants of SARS-CoV-2. Their research has yielded a wealth of insights and a few surprises.
By
  1. Cassandra Willyard

    1. Cassandra Willyard is a science journalist in Madison, Wisconsin.

A health worker transfers a dose of Moderna's COVID-19 vaccine into a syringe at a vaccination drive in a stadium in Manila

A health worker in the Philippines prepares a dose of COVID-19 vaccine during the January surge of Omicron cases. Credit: Basilio Sepe/ZUMA Wire/Shutterstock

No one anticipated how quickly Omicron would sweep the globe. Although the surge from the variant is starting to decline in many countries, worldwide case numbers are still on the rise. The last full week of January saw about 23 million confirmed new cases; previous peaks topped out at about 5 million per week. Beleaguered public-health officials are still scrambling to curtail the virus’s spread so that people with COVID-19 don’t overwhelm the hospitals.

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Nature 602, 22-25 (2022)

doi: https://doi.org/10.1038/d41586-022-00214-3

References

  1. Andrews, N. et al. Preprint at medRxiv https://doi.org/10.1101/2021.12.14.21267615 (2021).

  2. Tseng, H. F. et al. Preprint at medRxiv https://doi.org/10.1101/2022.01.07.22268919 (2021).

  3. Long, Q-.X. et al. Nature Med. 26, 1200–1204 (2020).

    Article  PubMed  Google Scholar 

  4. Ibarrondo, F. J. et al. N. Engl. J. Med. 383, 1085–1087 (2020).

    Article  PubMed  Google Scholar 

  5. Cohen, K. W. et al. Cell Rep. Med. 2, 100354 (2021).

    Article  PubMed  Google Scholar 

  6. Goel, R. R. et al. Science 374, eabm0829 (2021).

    Article  Google Scholar 

  7. Swadling, L. et al. Nature 601, 110–117 (2022).

    Article  PubMed  Google Scholar 

  8. Keeton, R. et al. Preprint at medRxiv https://doi.org/10.1101/2021.12.26.21268380 (2021).

  9. Gao, Y. et al. Nature Med. https://doi.org/10.1038/s41591-022-01700-x (2022).

    Article  Google Scholar 

  10. Chen, J. S. et al. Sci. Immunol. https://doi.org/10.1126/sciimmunol.abl5652 (2021).

    Article  Google Scholar 

  11. Garcia-Beltran, W. F. et al. Cell https://doi.org/10.1016/j.cell.2021.12.033 (2021).

    Article  Google Scholar 

  12. Tarke, A. et al. Cell https://doi.org/10.1016/j.cell.2022.01.015 (2022).

    Article  Google Scholar 

  13. UK Health Security Agency. SARS-CoV-2 Variants of Concern and Variants Under Investigation in England: Technical Briefing 33 (2021).

  14. Slifka, M. A. & Amanna, I. J. Front. Immunol. https://doi.org/10.3389/fimmu.2019.00956 (2019).

    Article  Google Scholar 

  15. Stuart, A. S. V. et al. Lancet 399, 36–49 (2022).

    Article  PubMed  Google Scholar 

Download references

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