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Powerful CRISPR system inserts whole gene into human DNA

‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems.
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  1. Elie Dolgin

    1. Elie Dolgin is a science journalist in Somerville, Massachusetts.

An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, precisely and efficiently, into human DNA.

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doi: https://doi.org/10.1038/d41586-025-01518-w

References

  1. Witte, I. P. et al. Science 388, eadt5199 (2025).

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  2. Fell, C. W. et al. Nature https://doi.org/10.1038/s41586-025-08877-4 (2025).

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  3. Liu, J. et al. Nature Commun. 16, 2427 (2025).

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  4. Perry, N. T. et al. Preprint at bioRxiv https://doi.org/10.1101/2025.05.14.653916 (2025).

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