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  • TECHNOLOGY FEATURE

Beyond AlphaFold: how AI is decoding the grammar of the genome

Scientists are seeking to decipher the role of non-coding DNA in the human genome, helped by a suite of artificial-intelligence tools.
By
  1. Jeffrey M. Perkel
A stylized illustration of an eyeball in the middle of a twisting DNA structure peering off to the side, on a green background.

Illustration: The Project Twins

In 1862, Victor Hugo reportedly wrote to his publisher to ask how his newly published novel Les Misérables was selling, with a single character query: “?” The response: “!”

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Nature 644, 829-832 (2025)

doi: https://doi.org/10.1038/d41586-025-02621-8

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