Treatment made that is effective against a wide range of snake venoms

Khalek, Irene S.; Jardine, Joseph G.

doi:10.1038/d41586-025-03216-z

NEWS AND VIEWS
29 October 2025

Treatment made that is effective against a wide range of snake venoms

Improved therapies to treat snakebite are needed. A new approach might lead to the development of more-effective treatments for use in the clinic.

By

Irene S. Khalek⁰ &
Joseph G. Jardine¹

Irene S. Khalek
1. Irene S. Khalek is in the Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, California 92037, USA.
View author publications

Search author on: PubMed Google Scholar
Joseph G. Jardine
1. Joseph G. Jardine is in the Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, California 92037, USA.
View author publications

Search author on: PubMed Google Scholar

Access through your institution

Buy or subscribe

In sub-Saharan Africa, snake bites are a major problem, and better antivenom treatments are required to prevent deaths and injuries. Writing in Nature, Ahmadi et al.¹ present a therapy that targets several snake venoms.

Access options

Access through your institution

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 647, 593-594 (2025)

doi: https://doi.org/10.1038/d41586-025-03216-z

References

Ahmadi, S. et al. Nature 647, 716–725 (2025).
Article Google Scholar
Hawgood, B. J. Toxicon 37, 1241–1258 (1999).
Article Google Scholar
Oliveira, A. L. et al. Nature Rev. Chem. 6, 451–469 (2022).
Article Google Scholar
Casewell, N. R. et al. Proc. Natl Acad Sci. USA 111, 9205–9210 (2014).
Article PubMed Google Scholar
Mackessy, S. P. (ed.) Handbook of Venoms and Toxins of Reptiles 1st edn (CRC Press, 2009).
Google Scholar
Bermúdez-Méndez, E. et al. Toxins 10, 452 (2018).
Article PubMed Google Scholar
Tasoulis, T. & Isbister, G. K. Toxins 18, 290 (2017).
Article Google Scholar
Menzies, S. K., Patel, R. N. & Ainsworth, S. Expert Opin. Drug Discov. 20, 799–819 (2025).
Article PubMed Google Scholar
Sørensen, C. V. et al. Toxicon 234, 107307 (2023).
Article PubMed Google Scholar
Ledsgaard, L. et al. Nature Commun. 14, 682 (2023).
Article PubMed Google Scholar
Khalek, I. S. et al. Sci. Transl. Med. 16, eadk1867 (2024).
Article PubMed Google Scholar
Glanville, J. et al. Cell 188, 3117–3134 (2025).
Article PubMed Google Scholar
Tasoulis, T. & Isbister, G. K. Toxins 9, 290 (2017).
Article PubMed Google Scholar
Sánchez, A. et al. J. Proteomics 15, 104–117 (2018).
Article Google Scholar

Download references

Reprints and permissions

Competing Interests

The authors declare no competing interests.

Subjects

Jobs

Postdoc in Computational Neurogenomics, Huang and Khoshkhoo Labs

Postdoc in Computational Genomics in Huang and Khoshkhoo Labs at Boston Children's Hospital, Brigham and Women’s Hospital, and Harvard Medical School

Longwood Medical Area, Boston, MA

Huang Lab at Boston Children's Hospital
Associate or Senior Editor, Nature Mechanical Engineering

Job Title: Associate or Senior Editor, Nature Mechanical Engineering Location: Shanghai, Beijing, Milan or Madrid - Hybrid Working Model Closing da...

Shanghai, Beijing, Milan or Madrid - Hybrid Working Model

Springer Nature Ltd
Associate or Senior Editor, Nature Mechanical Engineering

Job Title: Associate or Senior Editor, Nature Mechanical Engineering Location: Shanghai, Beijing, Milan or Madrid - Hybrid Working Model Closing da...

Shanghai, Beijing, Milan or Madrid - Hybrid Working Model

Springer Nature Ltd
Locum Associate or Senior Editor BMC Cancer and BMC Methods

Job Title: Locum Associate or Senior Editor BMC Cancer and BMC Methods Location: Shanghai or Pune, Hybrid Working Model Application Deadline: ...

Shanghai or Pune, Hybrid Working Model

Springer Nature Ltd
Associate or Senior Editor, Nature Communications (Battery)

Job title: Associate or Senior Editor, Nature Communications (Battery) Location: Shanghai, Beijing, Nanjing, Pune or New Delhi – hybrid working mod...

Shanghai, Beijing, Nanjing, Pune or New Delhi – hybrid working model

Springer Nature Ltd

[1] Ahmadi, S. et al. Nature 647, 716–725 (2025).
Article Google Scholar

[2] Hawgood, B. J. Toxicon 37, 1241–1258 (1999).
Article Google Scholar

[3] Oliveira, A. L. et al. Nature Rev. Chem. 6, 451–469 (2022).
Article Google Scholar

[4] Casewell, N. R. et al. Proc. Natl Acad Sci. USA 111, 9205–9210 (2014).
Article PubMed Google Scholar

[5] Mackessy, S. P. (ed.) Handbook of Venoms and Toxins of Reptiles 1st edn (CRC Press, 2009).
Google Scholar

[6] Bermúdez-Méndez, E. et al. Toxins 10, 452 (2018).
Article PubMed Google Scholar

[7] Tasoulis, T. & Isbister, G. K. Toxins 18, 290 (2017).
Article Google Scholar

[8] Menzies, S. K., Patel, R. N. & Ainsworth, S. Expert Opin. Drug Discov. 20, 799–819 (2025).
Article PubMed Google Scholar

[9] Sørensen, C. V. et al. Toxicon 234, 107307 (2023).
Article PubMed Google Scholar

[10] Ledsgaard, L. et al. Nature Commun. 14, 682 (2023).
Article PubMed Google Scholar

[11] Khalek, I. S. et al. Sci. Transl. Med. 16, eadk1867 (2024).
Article PubMed Google Scholar

[12] Glanville, J. et al. Cell 188, 3117–3134 (2025).
Article PubMed Google Scholar

[13] Tasoulis, T. & Isbister, G. K. Toxins 9, 290 (2017).
Article PubMed Google Scholar

[14] Sánchez, A. et al. J. Proteomics 15, 104–117 (2018).
Article Google Scholar

Access options

References

Competing Interests

Related Articles

Subjects

Latest on:

Jobs

Postdoc in Computational Neurogenomics, Huang and Khoshkhoo Labs

Associate or Senior Editor, Nature Mechanical Engineering

Associate or Senior Editor, Nature Mechanical Engineering

Locum Associate or Senior Editor BMC Cancer and BMC Methods

Associate or Senior Editor, Nature Communications (Battery)

Search

Quick links