Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here.

Close up of a black and white husky dog against a green alpine landscape.

Modern huskies have ancestral connections to early Arctic dogs.Credit: ventdusud/Panther Media Global via Alamy

People bred dogs thousands of years ago

The diversity of modern-day dog breeds might have emerged thousands of years ago. An analysis of ancient skulls reveals a distinctive dog skull shape — a shortened snout and widened face, compared to wolves — first seen in nearly 11,000-year-old fossils. Not long after, researchers say, there was a boom in the variety of dog skull shapes and sizes, capturing more than half of the diversity in today’s breeds. An analysis of the genomes of ancient dogs also suggests that ancient humans valued distinctive features, took their canine companions with them when they moved around and traded dogs with useful characteristics.

Nature | 5 min read

Reference: Science paper 1 and paper 2

Tiny robot allows magnetic drug delivery

A remote-controlled ‘robot’ the size of a grain of sand can swim through blood vessels to deliver drugs before dissolving into the body. The system uses tiny gelatine beads filled with a drug and nanoparticles of iron oxide, which allows its movement to be guided with a magnetic field. The ‘microrobots’, which have been tested in pigs and sheep, could allow doctors to deliver small doses of drugs to specific sites with less risk of toxic off-target effects.

Nature | 4 min read

Reference: Science paper

A looping animated sequence showing an insertion catheter with a gripper arm releasing a microrobot into a clear demonstration replica of a human vein.

Credit: ETH Zürich

Physics and mathematics in the age of AI

AI model taught itself basic physics

A system called AI-Newton, after being fed simulated experimental data, can autonomously ‘discover’ key physics principles, such as Newton’s second law. The model mimics the human scientific process by incrementally building a knowledge base of concepts and laws, says physicist Yan-Qing Ma, who helped to develop the system. It is far from making truly autonomous discoveries, but Ma thinks it could help develop future AI systems that use real-world data to discover new general laws of physics.

Nature | 5 min read

Reference: arXiv preprint (not peer reviewed)

AlphaProof proves its worth

Researchers have revealed the details of the technology behind AlphaProof, a tool designed to prove mathematical statements that did well at problems from last year’s International Mathematical Olympiad (IMO), a competition that sets tough maths problems for gifted high-school students. The achievement kicked off “a space race of sorts”, with other tools reaching gold-medal scores on this year’s IMO problems, writes proof-engineering researcher Talia Ringer. She shares insights gained by trying out AlphaProof herself.

Nature News & Views | 9 min read

Reference: Nature paper

The future of machine-augmented maths

AlphaProof is just one example of how artificial intelligence tools are reshaping the way mathematical research is conducted, write mathematicians Bartosz Naskręcki and Ken Ono. They think it’s unlikely that AI systems will solve deep problems that require the development of new theories. But they do expect that AI integration will transform mathematical practice. It could boost the need to formalize theorems and proofs into machine-readable formats, and make human creativity and insight even more valuable.

Nature Physics | 8 min read

News not to be missed

• Scientists have successfully stopped a pig kidney from being rejected by its human recipient for a record 61 days. (Nature | 5 min read)

• A small-scale AI model has outperformed some of the world’s best large language models in a series of logic puzzles. (Nature | 5 min read)

• The UK government has set itself an ambitious target: to produce a domestic trillion-dollar technology company by 2035. (Nature | 5 min read)

• Data indicate that geopolitical tensions are prompting scientists to reconfigure their global networks, which is impacting how nations collaborate in research. (Nature | 6 min read)

• A CRISPR–Cas9 gene-editing therapy has halved people’s cholesterol levels in a small clinical trial, raising hopes that gene-editing could one day tackle a leading cause of heart disease. (Nature | 5 min read)

Features & opinion

Futures: science fiction from Nature

A line cook takes comfort food very seriously in Hotcakes at the end times and an unwilling babysitter finally gets the recognition he deserves in Spaceport mementos.

Nature | 6 min read & Nature | 6 min read

Five best science books this week

Andrew Robinson’s pick of the top five science books to read this week includes an itemized study of ‘technofossils’ — the remnants of modern civilization — and an illustrated guide to the subtleties of typography.

Nature | 4 min read

Podcast: first sign of CME from another sun

Researchers have detected what they say is the strongest evidence yet of a coronal mass ejection (CME) — a huge expulsion of magnetized plasma — coming from a star other than our Sun. This changes everything for the study of CMEs, astronomer and study co-author David Konijn tells the Nature Podcast. While previous assumptions had to rely on the star we know best, “now we actually have this stellar data point”, he says. Next, “we're going to search through this entire data set very deliberately, very carefully to maybe find some more dimmer bursts”, says Konijn.

Nature Podcast | 27 min listen

Subscribe to the Nature Podcast on Apple Podcasts, Spotify or YouTube Music, or use the RSS feed.

Quote of the day

“If you’re affected, it means your brain’s working, and it doesn’t mean that something’s wrong.”

Vicarious trauma — psychological distress in individuals who are exposed to other people’s trauma through work — is an occupational hazard for some researchers, says gender-based violence researcher Millan AbiNader. She is one of many advocating for better workplace policies to ensure that such academics receive appropriate emotional support. (Nature | 5 min read)