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Can weight-loss pills replace injectables? What the science says

One pill for obesity is already on the market, and more are on the way. But the injected drugs have key advantages.
By
  1. Mariana Lenharo

    1. Mariana Lenharo is a reporter for Nature in New York City.

The weight-loss drugs that took the world by storm a few years ago have a drawback for anyone afraid of needles: they must be injected weekly. But scientists have been racing to perfect anti-obesity pills — which are now coming to market.

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doi: https://doi.org/10.1038/d41586-026-00856-7

References

  1. Wharton, S. et al. N. Engl. J. Med. 393, 1077–1087 (2025).

    Article  PubMed  Google Scholar 

  2. Wharton, S. et al. N. Engl. J. Med. 393, 1796–1806 (2025).

    Article  PubMed  Google Scholar 

  3. Jasreboff, A. M. et al. N. Engl. J. Med. 387, 205–216 (2022).

    Article  PubMed  Google Scholar 

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