Table 2 Single-point meta-analysis results summary
From: An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity
Meta-analysis type | Power (%) | False-positive rate (%) | 1 Causal variant found | 2 Causal variants found | 3 Causal variants found | 4 Causal variants found | 5 Causal variants found |
|---|---|---|---|---|---|---|---|
MAF ≥0.05 | |||||||
P-value based | 15.71 | 14.41 | 12.49 | 2.54 | 0.59 | 0.10 | 0 |
OR based (fixed effects) | 11.02 | 15.51 | 7.02 | 2.93 | 0.88 | 0.20 | 0 |
OR based (random effects) | 5.46 | 10.05 | 3.71 | 1.46 | 0.29 | 0 | 0 |
MAF <0.05 | |||||||
P-value based | 100 | 71.97 | 19.26 | 42.65 | 30.78 | 6.96 | 0.34 |
OR based (fixed effects) | 98.28 | 51.76 | 57.95 | 31.99 | 7.14 | 1.20 | 0 |
OR based (random effects) | 6.45 | 13.93 | 5.76 | 0.69 | 0 | 0 | 0 |
