Figure 3
From: Distal hereditary motor neuropathy in Korean patients with a small heat shock protein 27 mutation
T1-weighted magnetic resonance images (MRI) of the thighs and legs of a patient (V-30) with 15 years disease duration (A-C), and of patient IV-28 with 40 years disease duration (D-F). (A) Anterior coronal thigh image through femoral heads showing subtle fatty infiltration of the vastus muscle group. (B) Middle third axial thigh image showing subtle fatty infiltration of the posterior (BF, biceps femoris; Sm, semimembranosus; and St, semitendinosus) and anterior compartments, but preservation of the sartorius (Sr) and rectus femoris (RF) muscles. Medial compartments are intact. (C) Middle-third axial calf muscle image, showing severe fatty atrophy of the four compartment muscle groups, but a lower degree of anterolateral compartment muscle involvement. (D) Anterior coronal thigh image through femoral heads, showing marked and symmetric hyperintensity, indicative of fatty atrophy of the tensor fasciae latae (TFL) and vastus lateralis muscles, but sparing the gracilis (Gr) and sartorius (Sr) muscles. (E) Middle axial thigh image showing severe fatty atrophy of the posterior compartment and vastus muscle groups of the anterior compartment. Moderate fatty infiltration of the medial compartment and rectus femoris is shown (RF). The preservation of the gracilis (Gr) muscle was noted at this level. (F) Middle third axial calf image showing extensive fatty infiltrations of all four compartments. For comparative purposes the MR images of her daughter with a short disease duration are included (A-C), relatively severe thigh muscle involvements were evident in the mother.
