Figure 2 | Experimental & Molecular Medicine

Figure 2

From: Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2

Figure 2

Evaluation of the protein profiles of human indoleamine 2,3-dioxygenase 1 (hIDO1)-, hIDO2-, or hIDO1-2-overexpressing HEK293 stable cells using a proteomic approach. (a) Hierarchical clustering analysis of 159 differentially expressed proteins identified by analysis of variance at a false discovery rate <0.05. Scale bar at the top indicates fold change compared to mock control on a log2 scale. (b) Functional classifications of the 159 proteins. Significant biological classes were identified by Fisher’s exact test. The top six significant categories with P-values are shown. (c) Fold changes in expression of proteins related to cell survival/negative regulation of cell death, amino acid metabolism, and cell cycle compared with the mock control are plotted on a log2 scale.

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