Figure 1 | Experimental & Molecular Medicine

Figure 1

From: Sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells

Figure 1

DC migration induced by CCL21 treatment was not mediated by MAPKs. (a) At the indicated time points (0, 15, 30 and 120 min) before DC collection, CCL21 (25 ng ml−1)-treated DCs were prepared and analyzed via western blotting using antibodies against phospho ERK1/2, ERK1/2, p38, p38, pJNK and JNK. An anti-tubulin antibody was used as the internal control. The data are representative of three independent experiments. (b) DCs were treated with CCL21 (25 ng ml−1) for 2 h before getting collected in the absence or presence of the indicated MAPK inhibitors (U0126, SB203580 and SP600125), and the migratory capacities of mDCs were evaluated. The data are presented as the means±s.d. of three independent experiments.

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