Figure 4 | Experimental & Molecular Medicine

Figure 4

From: Sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells

Figure 4

SERCA2 regulation by CCL21 was mediated by the PLC and PKC pathways. CCL21-stimulated mDCs were treated with or without a PI3K inhibitor (wortmannin or LY294002), PLC inhibitor (U73122) or PKC inhibitor (BAPTA-AM) for 2 h before collection. (a) Migration assays were performed as described in the Materials and methods. The data are presented as the means±s.d. of three independent experiments. (b) Western blot analysis was performed as described in the Materials and methods. The data are representative of three independent experiments. The quantitative SERCA2/tubulin expression levels are shown using bar graphs, with statistical significances determined using Multi Gauge version 3.0, as described in the Materials and methods (*P<0.05).

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