Figure 1

Sensitivity to sorafenib is associated with glutamine synthetase (GS) expression levels in hepatocellular carcinoma (HCC) cells. (a) Representative western blots showing expression of GS in five HCC cell lines. (b) Results of cell viability assays performed 48 h after treatment with the indicated doses of sorafenib. IC50 values were compared using a Student t test. Data shown are means ± s.e’s. of the mean from three independent experiments. *P<0.01.