Abstract
The presence of fine epithelial deposits in a whorled pattern (cornea verticillata) as a consequence of treatment with amiodarone is well documented. We present a case of amiodarone keratopathy in a grafted cornea which is atypical in that the orientation of the pattern is rotated through nearly 90° to that normally observed. This observation runs counter to the hypothesis that cornea verticillata is a manifestation of the line of lid closure. We speculate on the mechanism directing the migrational pathways of epithelial cells.
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References
Wilson JS, Podrid PJ . Side effects from amiodarone. Am Heart J 1991;121:158–71.
Nielson CE, Andreasen F, Bjerregaard P . Amiodarone induced cornea verticillata. Acta Ophthalmol (Copenh) 1983;61:474–80.
Ingram DV, Jaggarao NSV, Chamberlain DA . Ocular changes resulting from therapy with amiodarone. Br J Ophthalmol 1982;66:676–9.
Orlando RG, Dangel ME, Schaal SE Clinical experience and grading of amiodarone keratopathy. Ophthalmology 1984;91:1184–7.
Kaplan LJ, Cappaert WE . Amiodarone keratopathy. Arch Ophthalmol 1982;100:601–2.
Klingele TJ, Alves LE, Rose ER Amiodarone keratopathy. Ann Ophthalmol 1984;16:1172–6.
Francois J . Cornea verticillata. Doc Ophthalmol 1969;27:235–50.
Bron AJ . Vortex patterns of the corneal epithelium. Trans Ophthalmol Soc UK 1973;93:455–72.
Gass JDM . The iron lines of the superficial cornea. Arch Ophthalmol 1964;71:348–58.
Feiler-Ofry V, Lazar M, Solomon A, Godel V . Amiodarone keratopathy. Ophthalmologica 1980;180:257–61.
Font RL, Fine BS . Ocular pathology in Fabry's disease. Am J Ophthalmol 1972;73:419–30.
Lullmann H, Lullmann-Rauch R, Wassermann O . Drug induced phospholipidoses. Crit Rev Toxicol 1975;4:185–218.
D'Amico DJ, Kenyon KR . Drug induced lipidoses of the cornea and conjunctiva. Int Ophthalmol 1981;4:67–76.
D'Amico DJ, Kenyon KR, Ruskin JN . Amiodarone keratopathy: drug induced lipid storage disease. Arch Ophthalmol 1981;99:257–61.
Whitley CB, Tsai MY, Heger JJ, Prystowsky EN, Zipes DP . Amiodarone phenocopy of Fabry's keratopathy. J Am Med Assoc 1983;249:2177–8.
Hirst LW, Sanborn G, Green WR, Miller NR, Heath WD . Amodiaquine ocular changes. Arch Ophthalmol 1982;100:1300–4.
Dua HS, Forrester JV . Clinical patterns of corneal epithelial wound healing. Am J Ophthalmol 1987;104:481–9.
Dua HS, Forrester JV . The corneoscleral limbus in human corneal epithelial wound healing. Am J Ophthalmol 1990;110:646–56.
Kaye DB . Epithelial responses in penetrating keratoplasty. Am J Ophthalmol 1980;89:381–7.
Kinoshita S, Friend J, Thoft RA . Sex chromatin of donor corneal epithelium in rabbits. Invest Ophthalmol Vis Sci 1981;21:434–41.
Thoft RA, Friend J . The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983;24:1442–3.
Tseng SCG . Concept and application of limbal stem cells. Eye 1989;3:141–57.
Williams PL, Warwick R . Gray's anatomy, 36th ed. Edinburgh: Churchill-Livingstone, 1983:157ff.
Garrett SN, Waterhouse WJ, Parmley VC . Amiodarone in the donor cornea. Am J Ophthalmol 1988;105:425–6.
Ohman L, Wahlberg I . Ocular side effects of clofazimine. Lancet 1975;2:933–4.
Walinder PE, Gip L, Stempa M . Corneal changes in patients treated with clofazimine. Br J Ophthalmol 1976;60:526–8.
Hedges TR, Kenyon KR, Hanninen LA, Mosher DB . Corneal and conjunctival effects of monobenzone in patients with vitiligo. Arch Ophthalmol 1983;101:64–8.
Weiss JN, Weinberg RS, Regelson W . Keratopathy after oral administration of tilorone hydrochloride. Am J Ophthalmol 1980;89:46–53.
Teich SA, Handwerger S, Mathur-Wagh U, Yancovitz S, Desnick RJ, Mildvan D . Toxic keratopathy associated with suramin therapy. N Engl J Med 1986;314:1455–6.
Szmyd L, Perry HD . Keratopathy associated with the use of naproxen. Am J Ophthalmol 1985;99:598.
Bernstein HN . Some iatrogenic ocular diseases from systemically administered drugs. Int Ophthalmol Clin 1970;10:553–619.
Hobbs HE, Eadie SP, Somerville F . Ocular lesions after treatment with chloroquine. Br J Ophthalmol. 1961;45:284–97.
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Rogers, N., Bowen, D. & Noble, B. Development of atypical amiodarone keratopathy in a corneal graft. Eye 7, 594–596 (1993). https://doi.org/10.1038/eye.1993.129
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DOI: https://doi.org/10.1038/eye.1993.129


