Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Bacon AS, Dart JKG, Ficker LA, Matheson MH, Wright P . Acanthamoeba keratitis: the value of early diagnosis. Ophthalmology 1993;100:1238–43
Hay J, Kirkness CM, Seal DV, Wright P . Drug resistance and Acanthamoeba keratitis: the quest for alternative anti-protozoal chemotherapy. Eye 1994;8:555–63.
Tay-Kearney M-L, McGhee CNJ, Crawford GJ, Trown K . Acanthamoeba keratitis: a masquerade of presentation in six cases. Aust NZ J Ophthalmol 1993;21:237–45.
Sharma S, Srinivasan M, George C . Acanthamoeba keratitis in non-contact lens wearers. Arch Ophthalmol 1990;108:676–8.
D'Aversa G, Stern GA, Driebe WT Jr. Diagnosis and successful medical treatment of Acanthamoeba keratitis. Arch Ophthalmol 1995;113:1120–3.
Bacon AS, Frazer DG, Dart JKG, Matheson M, Ficker LA, Wright P . A review of 72 consecutive cases of Acanthamoeba keratitis. Eye 1993;7:719–25.
Gray TB, Gross KA, Cursons RTM, Shewan JF . Acanthamoeba keratitis: a sobering case and a promising new treatment. Aust NZ J Ophthalmol 1994;22:73–6.
Seal DV, Hay J, Kirkness CM, Morrell A, Booth A, Tullo A, Ridgway A, Armstrong M . Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. Eye 1996;10:413–21.
Jones DB . Acanthamoeba — the ultimate opportunist? Am J Ophthalmol 1986;102:527–30.
Klink van F, Alizadeh H, Ye YG . A Chinese hamster model of Acanthamoeba keratitis: role of contact lenses, trauma and Langerhans cells. Invest Ophthalmol Vis Sci 1993;34:1937–44.
Panjwani N, Zhao Z, Baum J, Pereira M, Zaidi T . Acanthamoebae bind to glycolipids of rabbit corneal epithelium. Infect Immun 1992;60:3460–3.
Garner A . Pathogenesis of acanthamoebic keratitis: hypothesis based on a histological analysis of 30 cases. Br J Ophthalmol 1993;77:366–70.
Mathers W, Stevens GS Jr, Rodrigues M, Chan CC, Gold J, Visvesvara GS, Lemp MA, Zimmerman LE . Immunopathology and electron microscopy of Acanthamoeba keratitis. Am J Ophthalmol 1987;103:626–35.
Klink van F, Taylor WM, Alizadeh H, Jager MJ, Rooyen van N, Niederkorn JY . The role of macro-phages in Acanthamoeba keratitis. Invest Ophthalmol Vis Sci 1996;37:1271–81.
Badenoch PR, Adams M, Coster DJ . Corneal virulence, cytopathic effect on human keratocytes and genetic characterisation of Acanthamoeba. Int J Para-sitol 1995;25:229–39.
Rivasi F, Langanesi L, Casobari C, Croppo GP, Pierini G, Zunarelli E, Visvesvara GS . Cytologie diagnosis of Acanthamoeba keratitis: report of a case with correlative study with indirect immunofluorescence and scanning electron microscopy. Acta Cytol 1995;39:821–6.
Moore MB, Ubelaker JE, Martin JH, Silvany R, Dougherty JM, Meyer DR, McCulley JP . In vitro penetration of human corneal epithelium by Acanthamoeba castellanii: a scanning and transmission microscopy study. Cornea 1991;10:291–8.
Stopak SS, Roat MI, Nauheim RC, Turgeon PW, Sossi G, Kowalski RP, Thoft RA . Growth of Acanthamoeba on human corneal epithelial cells and keratocytes in vitro. Invest Ophthalmol Vis Sci 1991;32:354–9.
Aitken DA, Beirouty A, Lee WR . Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome. Br J Ophthalmol 1995;79:282–9.
Dua HS, Watson NJ, Mathur RM, Forrester JV . Corneal epithelial cell migration in humans: ‘hurricane and blizzard keratopathy’. Eye 1993;7:53–8.
Ren H, Wilson G . Apoptosis in the corneal epithelium. Invest Ophthalmol Vis Sci 1996;37:1017–25.
Brown T . Observations by immunofluorescence morphology on the cytopathogenicity of Naegleria fowleri in mouse embryo-cell cultures. J Med Microbiol 1979;12:363–71.
Aitken D, Hay J, Kinnear FB, Kirkness CM, Lee WR, Seal DV . Amebic keratitis in a wearer of disposable contact lenses due to a mixed Vahlkampfia and Hartmanella infection. Ophthalmology 1996;103:485–94.
Russell AD . Chlorhexidine: microbicidal action and bacterial resistance. Infection 1986;14:212–5.
Nisbet IT, Graham DM, Spicer PE, Tibbs GJ . Chlorhexidine is an effective agent against Chlamydia trachomatis in vitro and in vivo. Antimicrob Agents Chemother 1979;16:855–7.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cassella, J., Hay, J. & Seal, D. Rational drug targeting in Acanthamoeba keratitis: Implications of host cell-protozoan interaction. Eye 11, 751–754 (1997). https://doi.org/10.1038/eye.1997.190
Issue date:
DOI: https://doi.org/10.1038/eye.1997.190