Abstract
Aims
To study the effect of haemodialysis on intraocular pressure (IOP) of patients at the University Malaya Medical Centre, Kuala Lumpur, and the influence of anterior chamber angles, surgery, and diabetes on the change in IOP after haemodialysis.
Methods
Prospective, single centre study on patients undergoing haemodialysis with a sample size of 98 eyes (49 patients). Ocular examination was performed before haemodialysis. Pre- and post-haemodialysis IOP measurements were taken. Plasma osmolarity changes and volume of fluid removed were noted. Patients on antiglaucoma treatment or who have had earlier laser or surgical procedures for it were excluded. Student's t-test and Pearson's coefficient test were used to determine the statistical significance.
Results
Plasma osmolarity decreased significantly (−11.6±10.0mOsm/l, P<0.001). In eyes with occludable angles (8% of cases), IOP decreased significantly (−3.63±1.92 mmHg, P<0.001). In non-occludable angle eyes (92% of cases), no significant changes (P>0.05) in all subgroups of non-operated/operated and diabetic/non-diabetic eyes were seen.
Conclusions
Haemodialysis does not cause significant changes in IOP in non-glaucomatous and non-occludable angle eyes.
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References
Lim YN, Lim TO . 14th Report of the Malaysian Dialysis and Transplant Registry. National Renal Registry, Malaysian Society of Nephrology: Kuala Lumpur, 2006.
Arikan H, Tuglular S . The growing global burden of end stage renal disease (ESRD). Marmara Med J 2005; 18: 143–150.
Renal Replacement Therapy Clinical Practice Guidelines, 2nd edn. Nephrology Working Group, Ministry of Health: Malaysia, 2005.
Diaz-Couchoud P, Bordas FD, Garcia JRF, Camps EM, Carceller A . Corneal disease in patients with chronic renal insufficiency undergoing haemodialysis. Cornea 2001; 20: 695–702.
Basile C, Addabbo G, Montanaro A . Anterior ischaemic optic neuropathy and dialysis: role of hypotension and anaemia. J Nephrol 2001; 14: 420–423.
Al-Falki YH . Bilateral occipital infarcts in a haemodialysis patient. Am J Nephrol 2001; 21: 413–414.
Romero CF, Rai MK, Lowder CY, Adal KA . Endogenous endophthalmitis: case report and brief review. Am Fam Physician 1999; 60: 510–514.
Fleischhauer J, Keusch G, Abegg MH . Rise in intraocular pressure during haemodialysis in a patient with reduced outflow facility. Br J Ophthalmol 2007; 91: 1091–1093.
Masuda H, Shibuya Y, Ohira A . Markedly increased unilateral intraocular pressure during haemodialysis in a patient with ipsilateral exfoliative glaucoma. Am J Ophthalmol 2000; 129: 534–536.
Choong YF, Menage MJ . Symptomatic acute raised IOP following haemodialysis in a patient with end stage renal failure. Br J Ophthalmol 1998; 82: 1339a.
Austin JN, Klein M, Mishell J, Contiguglia SR, Levy J, Chan L et al. Intraocular pressures during high-flux haemodialysis. Ren Fail 1990; 12: 109–112.
Sitprija V, Holmes JH, Ellis PP . Intraocular pressure changes during artificial kidney therapy. Arch Ophthalmol 1964; 72: 626–631.
Costagliola C, Mastropasqua L . The influence of haemodialysis on intraocular pressure: III. Aqueous humour dynamics and tissue hydration. Ann Ophthalmol 1991; 23: 31–34.
Tawara A, Kobata H, Fujisawa K, Abe T, Ohnishi Y . Mechanism of intraocular pressure elevation during haemodialysis. Curr Eye Res 1998; 17: 339–347.
Tokuyama T, Ikeda T, Sato K . Effect of plasma colloid osmotic pressure on intraocular pressure during haemodialysis. Br J Ophthalmol 1998; 82: 751–753.
Doshiro A, Ban Y, Kobayashi L, Yoshida Y, Uchiyama H . Intraocular pressure change during haemodialysis. Am J Ophthalmol 2006; 142: 337–339.
Levy J, Tovbin D, Lifshitz T, Zlotnik M, Tessler Z . Intraocular pressure during haemodialysis: a review. Eye 2005; 19: 1249–1256.
Foster PJ, Aung T, Nolan WP, Machin D, Baasanhu J, Khaw PT et al. Defining ‘occludable’ angles in population surveys: drainage angle width, peripheral anterior synechiae, and glaucomatous optic neuropathy in East Asian people. Br J Ophthalmol 2004; 88: 486–490.
Yoon YH, Sohn JH, Lee SE, Lee YB, Kim JY, Kook MS . Increase in intraocular pressure during haemodialysis in eyes during early postvitrectomy period. Ophthalmic Surg Lasers 2000; 31: 467–473.
Li AF, Tane N, Roy S . Fibronectin overexpression inhibits trabecular meshwork cell monolayer permeability. Mol Vis 2004; 10: 750–757n.
Acknowledgements
This study received a University Malaya Postgraduate Research Grant (ref PS291/2007B). This funding source did not have any other involvement or direct financial interest in this study.
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Samsudin, A., Mimiwati, Z., Soong, T. et al. Effect of haemodialysis on intraocular pressure. Eye 24, 70–73 (2010). https://doi.org/10.1038/eye.2009.33
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DOI: https://doi.org/10.1038/eye.2009.33
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