Abstract
Purpose
To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs).
Design
Retrospective case–control study.
Participants
Nineteen patients who had macular oedema due to BRVO and nine patients with non-ischaemic ocular diseases (control group).
Methods
Macular oedema was examined by optical coherence tomography. Both venous blood and vitreous samples were obtained at the time of vitreoretinal surgery. IL-8 and MCP-1 levels in vitreous fluid and plasma were determined with enzyme-linked immunosorbent assay kits. Variables were compared with the Mann–Whitney U-test, Wilcoxon's signed-ranked test, and the χ2-test, when appropriate. To examine correlations, Spearman's rank-order correlation coefficients were calculated. Statistical significance was set at P<0.05.
Results
The vitreous fluid levels of IL-8 (median: 63.5 pg/ml) and MCP-1 (median: 1522.4 pg/ml) were significantly higher in the patients with BRVO than in the control group (median: 5.1 and 746.5 pg/ml respectively; P<0.001 and <0.001 respectively). Vitreous IL-8 and MCP-1 were significantly correlated in patients with BRVO (P=0.009).
Conclusions
Both IL-8 and MCP-1 were elevated in the vitreous fluid of patients with BRVO and macular oedema. Both chemokines may contribute to the pathogenesis of macular oedema in patients with BRVO.
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Acknowledgements
This study was financially supported by Instituto de Salud Carlos III, Madrid, Grant number FIS PI/060803.
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This study was partially presented in 2009 ARVO meeting as a poster.
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Fonollosa, A., Garcia-Arumi, J., Santos, E. et al. Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion. Eye 24, 1284–1290 (2010). https://doi.org/10.1038/eye.2009.340
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DOI: https://doi.org/10.1038/eye.2009.340
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