Abstract
Purpose
To evaluate the relationship between visual acuity as measured by the Early Treatment Diabetic Retinopathy Study (ETDRS) chart and by the potential acuity meter (PAM) with retinal thickness and sensitivity measured by a combined microperimetry/optical coherence tomography system (OCT).
Methods
Forty-four patients with macular edema (ME) were included in a prospective observational study. Visual acuity (VA) was assessed using the ETDRS chart (with best correction) as well as by the PAM. Retinal thickness and sensitivity was measured by an automatic fundus perimetry/tomography system.
Results
Best-corrected VA using the ETDRS chart ranged from 20/20 to 20/400 (median: 20/50). VA measured by the PAM without correction ranged from 20/20 to 20/400 (median: 20/40). The mean retinal thickness was 369.57 μm (s.d.: 140.28 μm) on spectral domain-OCT and the mean retinal sensitivity was 8.12 decibels (dB) (s.d.: 5.78 dB). The mean LogMAR value using the ETDRS chart was 0.43, whereas it was 0.38 using the PAM (P-value: 0.009).
Conclusions
VA values measured by the PAM were statistically significantly better than those measured by the ETDRS chart in eyes with ME secondary to various retinal vascular and uveitic diseases. VA measured by the PAM may be a more sensitive predictor of macular function than that obtained by ETDRS testing in eyes with ME.
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Acknowledgements
The scanning laser ophthalmoscope/spectral domain optical coherence tomography unit (SLO/OCTTM) is on loan from Optos, Inc., UK, to the Johns Hopkins Medical Institution for research and clinical care. The study was supported in part through a Physician Scientist Award from Research to Prevent Blindness (QDN), as well as by the Macular Research Fund and the Pediatric Ophthalmology and Strabismus Research Grant Award, Wilmer Eye Institute, the Johns Hopkins University School of Medicine (EH).
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The study was presented in part at the Association for Research in Vision and Ophthalmology Annual Meeting, May 2012, Fort Lauderdale, Florida.
Disclaimer
Dr Guyton was one of the inventors of the PAM and the Prevue prototype but no longer has any financial interest in their sale or use. The sponsor or funding organization had no role in the design or conduct of this research.
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Hatef, E., Hanout, M., Moradi, A. et al. Longitudinal comparison of visual acuity as measured by the ETDRS chart and by the potential acuity meter in eyes with macular edema, and its relationship with retinal thickness and sensitivity. Eye 28, 1239–1245 (2014). https://doi.org/10.1038/eye.2014.182
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DOI: https://doi.org/10.1038/eye.2014.182
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