Abstract
Purpose
To investigate the changes of intraocular pressure (IOP) and anterior eye segment biometric parameters under different accommodative statuses in progressing myopes and emmetropes.
Methods
Forty-six progressing myopes and 40 emmetropes participated in this study. All the subjects had their IOP and anterior eye segment biometric parameters (including corneal thickness, anterior chamber depth, anterior chamber angle width, and lens thickness) measured using iCare rebound tonometer and VisanteTM anterior segment-optical coherence tomography while accommodative stimuli of 0, 3, and 6D were presented.
Results
There was no significant difference in IOP between progressing myopes and emmetropes when no accommodation was induced (16.22±4.11 vs 17.01±3.72, respectively, t=−0.93, P>0.05). However, IOP significantly increased with accommodation in progressing myopes (mean change +1.02±2.07 mm Hg from 0D to 6D, F=5.35, P<0.01), but remained unchanged (mean change −0.76±3.22 mm Hg from 0D to 6D, F=1.46, P>0.05) in emmetropes. Meanwhile, we found that their anterior chamber depth decreased (P<0.01), anterior chamber angle narrowed (P<0.01), and lens thickened (P<0.01) significantly with accommodation, both in progressing myopes and emmetropes.
Conclusions
Although no difference was detected between the IOPs of progressing myopes and emmetropes without accommodation, accommodation could induce transient IOP elevation in progressing myopes. Simultaneously, we found that their anterior chamber depth decreased, anterior chamber angle narrowed, and lens thickened with accommodation. Although emmetropes showed the similar anterior eye segment structure changes, their IOPs did not increase with accommodation. Our study indicated that IOP elevation with accommodation in progressing myopes might be related to myopia progression.
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References
Saw SM, Zhang MZ, Hong RZ, Fu ZF, Pang MH, Tan DT . Near-work activity, night-lights, and myopia in the Singapore-China study. Arch Ophthalmol 2002; 120 (5): 620.
Mutti DO, Mitchell GL, Moeschberger ML, Jones LA, Zadnik K . Parental myopia, near work, school achievement, and children’s refractive error. Invest Ophthalmol Vis Sci 2002; 43 (12): 3633–3640.
Smith EL, Kee C, Ramamirtham R, Qiao-Grider Y, Hung LF . Peripheral vision can influence eye growth and refractive development in infant monkeys. Invest Ophthalmol Vis Sci 2005; 46 (11): 3965–3972.
Gwiazda JE, Hyman L, Norton TT, Hussein ME, Marsh-Tootle W, Manny R et al. Accommodation and related risk factors associated with myopia progression and their interaction with treatment in COMET children. Invest Ophthalmol Vis Sci 2004; 45 (7): 2143–2151.
Gwiazda J, Thorn F, Held R . Accommodation, accommodative convergence, and response AC/A ratios before and at the onset of myopia in children. Optom Vis Sci 2005; 82 (4): 273–278.
Jichun X . Relation between increase of intraocular pressure induced by durative near-work and development of myopia. Chin J Mod Eye Ear Nose Throat 2009; 6 (1): 11–13.
Mutti DO, Mitchell GL, Hayes JR, Jones LA, Moeschberger ML, Cotter SA et al. Accommodative lag before and after the onset of myopia. Invest Ophthalmol Vis Sci 2006; 47 (3): 837–846.
Curtin BJ . The Myopias: Basic Science and Clinical Management. Harper & Row: Philadelphia, 1985.
Tomlinson A, Phillips CI . Applanation tension and axial length of the eyeball. Br J Ophthalmol 1970; 54 (8): 548.
Jensen H . Myopia progression in young school children and intraocular pressure. Doc Ophthalmol 1992; 82 (3): 249–255.
Nomura H, Ando F, Niino N, Shimokata H, Miyake Y . The relationship between intraocular pressure and refractive error adjusting for age and central corneal thickness. Ophthalmic Physiol Opt 2004; 24 (1): 41–45.
Lee AJ, Saw SM, Gazzard G, Cheng A, Tan DT . Intraocular pressure associations with refractive error and axial length in children. Br J Ophthalmol 2004; 88 (1): 5–7.
Manny RE, Deng L, Crossnoe C, Gwiazda J . IOP, myopic progression and axial length in a COMET subgroup. Optom Vis Sci 2008; 85 (2): 97–105.
Read SA, Collins MJ, Iskander DR . Diurnal variation of axial length, intraocular pressure, and anterior eye biometrics. Invest Ophthalmol Vis Sci 2008; 49 (7): 2911–2918.
Leydolt C, Findl O, Drexler W . Effects of change in intraocular pressure on axial eye length and lens position. Eye 2007; 22 (5): 657–661.
Nickla DL, Wildsoet CF, Troilo D . Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset. Invest Ophthalmol Vis Sci 2002; 43 (8): 2519–2528.
Vera-Díaz FA, Strang NC, Winn B . Nearwork induced transient myopia during myopia progression. Curr Eye Res 2002; 24 (4): 289–295.
Read SA, Collins MJ, Woodman EC, Cheong SH . Axial length changes during accommodation in myopes and emmetropes. Optom Vis Sci 2010; 87 (9): 656–662.
Young FA . The development and control of myopia in human and subhuman primates. Contacto 1975; 19 (6): 16–31.
Walker TW, Mutti DO . The effect of accommodation on ocular shape. Optom Vis Sci 2002; 79 (7): 424–430.
Woodman EC, Read SA, Collins MJ, Hegarty KJ, Priddle SB, Smith JM et al. Axial elongation following prolonged near work in myopes and emmetropes. Br J Ophthalmol 2011; 95 (5): 652–656.
Mallen EAH, Kashyap P, Hampson KM . Transient axial length change during the accommodation response in young adults. Invest Ophthalmol Vis Sci 2006; 47 (3): 1251–1254.
Read SA, Collins MJ, Becker H, Cutting J, Ross D, Savill AK et al. Changes in intraocular pressure and ocular pulse amplitude with accommodation. Br J Ophthalmol 2010; 94 (3): 332–335.
Mauger RR, Likens CP, Applebaum M . Effects of accommodation and repeated applanation tonometry on intraocular pressure. Am J Optom Physiol Opt 1984; 61 (1): 28.
Jenssen F, Krohn J . Effects of static accommodation versus repeated accommodation on intraocular pressure. J Glaucoma 2012; 21 (1): 45–48.
Feltgen N, Leifert D, Funk J . Correlation between central corneal thickness, applanation tonometry, and direct intracameral IOP readings. Br J Ophthalmol 2001; 85 (1): 85–87.
Kida T, Liu JHK, Weinreb RN . Effect of 24-hour corneal biomechanical changes on intraocular pressure measurement. Invest Ophthalmol Vis Sci 2006; 47 (10): 4422–4426.
David R, Zangwill L, Briscoe D, Dagan M, Yagev R, Yassur Y . Diurnal intraocular pressure variations: an analysis of 690 diurnal curves. Br J Ophthalmol 1992; 76 (5): 280–283.
Tsukahara S, Sasaki T . Postural change of IOP in normal persons and in patients with primary wide open-angle glaucoma and low-tension glaucoma. Br J Ophthalmol 1984; 68 (6): 389–392.
Jorge JMM, Gonzalez-Meijome JM, Queiros A, Fernandes P, Parafita MA . Correlations between corneal biomechanical properties measured with the ocular response analyzer and ICare rebound tonometry. J Glaucoma 2008; 17 (6): 442–448.
Drexler W, Baumgartner A, Findl O, Hitzenberger CK, Fercher AF . Biometric investigation of changes in the anterior eye segment during accommodation. Vis Res 1997; 37 (19): 2789–2800.
Huang J, Qu X, Chu R, Chu X . Analysis of the anterior segment of the eyes of adolescent myopes when accommodation is induced by different reading distances. Chin J Optom Ophthalmol 2008; 10 (2): 92–95.
Schreiber W, Vorwerk CK, Langenbucher A, Behrens-Baumann W, Viestenz A . [A comparison of rebound tonometry (ICare) with TonoPenXL and Goldmann applanation tonometry]. Ophthalmologe 2007; 104 (4): 299–304.
Vandewalle E, Vandenbroeck S, Stalmans I, Zeyen T . Comparison of ICare, dynamic contour tonometer, and ocular response analyzer with Goldmann applanation tonometer in glaucoma. Eur J Ophthalmol 2009; 19 (3): 783–789.
Brusini P, Salvetat ML, Zeppieri M, Tosoni C, Parisi L . Comparison of ICare tonometer with Goldmann applanation tonometer in glaucoma patients. J Glaucoma 2006; 15 (3): 213–217.
Muttuvelu DV, Baggesen K, Ehlers N . Precision and accuracy of the ICare tonometer–peripheral and central IOP measurements by rebound tonometry. Acta Ophthalmol 2012; 90 (4): 322–326.
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Yan, L., Huibin, L. & Xuemin, L. Accommodation-induced intraocular pressure changes in progressing myopes and emmetropes. Eye 28, 1334–1340 (2014). https://doi.org/10.1038/eye.2014.208
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DOI: https://doi.org/10.1038/eye.2014.208
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