Abstract
Purpose
To assess the safety and efficacy of a single session of subthreshold micropulse (SM) yellow laser (577 nm) in the treatment of chronic central serous chorioretinopathy (CSCR).
Methods
This was a retrospective analysis of 15 eyes of 13 patients with CSCR of >3 months duration who had been treated with SM yellow laser (577 nm). All patients had been treated using multiple spots of laser with a duty cycle of 10% over areas of focal and diffuse leak, as seen on fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA). Reduction in subretinal fluid height on spectral domain optical coherence tomography (SD-OCT) was used to measure the response to treatment.
Results
The mean follow-up was at 8 weeks (4–19 weeks). All eyes responded to treatment. The mean subretinal fluid height pre and post treatment was 232 and 49 μm, respectively, showing a 79% average reduction (P<0.001) in fluid height. There was no evidence of retinal pigment epithelium or retinal damage on SD-OCT, FFA, or fundus autofluorescence. Median visual improvement was one line on Snellen’s visual acuity chart (P=0.015). Microperimetry was performed in eight eyes of which six eyes (75%) showed an improvement in the threshold values post treatment.
Conclusion
SM yellow laser is an effective treatment option for chronic CSCR.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Spaide RF, Goldbaum M, Wong DWK, Tang KC, Iida T . Serous detachment of the retina. Retina 2003; 23: 820–846.
Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Ho A, Orlock D . Digital indocyanine green videoangiography of central serous chorioretinopathy. Arch Ophthalmol 1994; 112: 1057–1062.
Gilbert CM, Owens SL, Smith PD, Fine SL . Long-term follow-up of central serous chorioretinopathy. Br J Ophthalmol 1984; 68: 815–820.
Loo RH, Scott IU, Flynn HW Jr, Gass JD, Murray TG, Lewis ML et al. Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy. Retina 2002; 22: 19–24.
Bujarborua D . Long-term follow-up of idiopathic central serous chorioretinopathy without laser. Acta Ophthalmol Scand 2001; 79: 417–421.
Yannuzzi LA . Central serous chorioretinopathy: a personal perspective. Am J Ophthalmol 2010; 149: 361–363.
Chan WM, Lai TY, Lai RY, Tang EW, Liu DT, Lam DS . Safety enhanced photodynamic therapy for chronic central serous chorior- etinopathy: one-year results of a prospective study. Retina 2008; 28: 85–93.
Khosla PK, Rana SS, Tewari HK, Azad RU, Talwar D . Evaluation of visual function following argon laser photocoagulation in central serous retinopathy. Ophthalmic Surg Lasers 1997; 28: 693–697.
Ober MD, Yannuzzi LA, Do DV, Spaide RF, Bressler NM, Jampol LM et al. Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy. Ophthalmology 2005; 112: 2088–2094 30.
Chung YR, Seo EJ, Lew HM, Lee KH . Lack of positive effect of intravitreal bevacizumab in central serous chorioretinopathy: meta-analysis and review. Eye(Lond) 2013; 27 (12): 1339–1346.
Shatz H, Yannuzzi LA, Gitter KA . Subretinal neovascularization following argon laser photocoagulation treatment for central serous chorioretinopathy: complication or misdiagnosis? Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol 1977; 83: 893–906.
Maruko I, Iida T, Sugano Y, Ojima A, Ogasawara M, Spaide RF . Subfoveal choroidal thickness after treatment of central serous chorioretinopathy. Ophthalmology 2010; 117: 1792–1799.
Mainster MA Laser-tissue interactions: future laser therapies. In: Diabetic Retinopathy: Approaches to a Global Epidemic. Association for Research in Vision and Ophthalmology Summer Research Conference 2010. Natcher Center, National Institutes of Health, Bethesda MD, 31 July 2010.
Mainster MA . Decreasing retinal photocoagulation damage: Principles and techniques. Semin Ophthalmol 1999; 14: 200–209.
Yadav NK, Jayadev C, Rajendran A, Nagpal M . Recent developments in retinal lasers and delivery systems. Indian J Ophthalmol 2014; 62: 50–54.
Lanzetta P, Furlan F, Morgante L, Veritti D, Bandello F . Nonvisible subthreshold micropulse diode laser (810 nm) treatment of central serous chorioretinopathy. A pilot study. Eur J Ophthalmol 2008; 18 (6): 934–940.
Ricci F, Missiroli F, Regine F, Grossi M, Dorin G . Indocyanine green enhanced subthreshold diode-laser micropulse photocoagulation treatment of chronic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 2009; 247 (5): 597–607.
Chen SN, Hwang JF, Tseng LF, Lin CJ . Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. Ophthalmology 2008; 115 (12): 2229–2234.
Joondeph BC, Joondeph HC, Blair NP . Retinal macroaneurysms treated with the yellow dye laser. Retina 1989; 9: 187–192.
Siviprasad S, Sandhu R, Tandon A, Sayed-Ahmed K, McHugh DA . Subthreshold micropulse diode laser photocoagulation for clinically significant diabetic macular oedema: a three-year follow-up. Clin Experiment Ophthalmol 2007; 35 (7): 640–644.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Yadav, N., Jayadev, C., Mohan, A. et al. Subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy: safety profile and treatment outcome. Eye 29, 258–265 (2015). https://doi.org/10.1038/eye.2014.315
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/eye.2014.315
This article is cited by
-
Half-dose photodynamic therapy versus 577 nm subthreshold pulse laser therapy in treatment-naive patients with central serous chorioretinopathy
BMC Ophthalmology (2024)
-
The effect of nondamaging subthreshold laser therapy in patients with chronic central serous chorioretinopathy
Graefe's Archive for Clinical and Experimental Ophthalmology (2024)
-
Central serous chorioretinopathy: updates in the pathogenesis, diagnosis and therapeutic strategies
Eye and Vision (2023)
-
Structure and spectral properties of Dy3+ doped CaYAlO4 single crystal
Scientific Reports (2023)
-
Randomized controlled trials in central serous chorioretinopathy: A review
Eye (2023)
