Abstract
Purpose
To correlate the structure of the macula, as measured by spectral-domain optical coherence tomography (SD-OCT) and function, as measured by microperimetry (MAIA) in patients with retinitis pigmentosa (RP) and relatively good visual acuity.
Design
Prospective, cross-sectional, non-intervention study.
Subjects
Patients with RP.
Methods
Thirty patients with RP and good central visual acuity were identified. Each patient underwent SD-OCT of the macula and microperimetry. The images were overlaid using the custom-designed software. The retinal sensitivity by microperimetry was correlated with corresponding retinal thickness, as measured by the SD-OCT. ELM, COST, and IS/OS junction were scored as intact, disrupted, or absent.
Main outcome measures
Comparing the retinal sensitivity on the MAIA with various measurements on the SD-OCT.
Results
The retinal sensitivity on the MAIA showed a significant correlation with total retinal thickness and outer retinal thickness on the SD-OCT. There was no association with either the inner retinal thickness or the choroidal thickness. ORT showed a statistically significant correlation with the anatomical classification of ELM (r=−0.76, P<0.001), IS/OS (r=−0.800, P<0.001), and COST (r=−0.733, P<0.001).
Conclusion
This study determined that there was a high correlation of the structure and function of the central macula in patients with RP. These studies are important to establish surrogate markers that can be used as end points for various tests in future therapeutic clinical trials.
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References
Fishman GA . Retinitis pigmentosa. Genetic percentages. Arch Ophthalmol 1978; 96: 822–826.
Hamel C . Retinitis pigmentosa. Orphanet J Rare Dis 2006; 1: 40.
Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE et al. Argus II Study Group. Interim results from the international trial of Second Sight's visual prosthesis. Ophthalmology 2012; 119: 779–788.
Tan MH, Smith AJ, Pawlyk B, Xu X, Liu X, Bainbridge JB et al. Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Hum Mol Genet 2009; 18: 2099–2114.
Bennett J . Gene therapy for retinitis pigmentosa. Curr Opin Mol Ther 2000; 2: 420–425.
Chader GJ, Weiland J, Humayun MS . Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res 2009; 175: 317–332.
MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L et al. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. Lancet 2014; 383: 1129–1137.
Rohrschneider KS, Bultmann, Springer C . Use of fundus perimetry (microperimetry) to quantify macular sensitivity. Prog Retin Eye Res 2008; 27: 536–548.
Sugawara T, Sato E, Baba T, Hagiwara A, Tawada A, Yamamoto S . Relationship between vision-related quality of life and microperimetry-determined macular sensitivity in patients with retinitis pigmentosa. Jpn J Ophthalmol 2011; 55: 643–646.
Sugawara T, Hagiwara A, Hiramatsu A, Ogata K, Mitamura Y, Yamamoto S . Relationship between peripheral visual field loss and vision-related quality of life in patients with retinitis pigmentosa. Eye 2010; 24: 535–539.
Tawada A, Sugawara T, Ogata K, Hagiwara A, Yamamoto S . Improvement of central retinal sensitivity six months after topical isopropyl unoprostone in patients with retinitis pigmentosa. Indian J Ophthalmol 2013; 61: 95–99.
Alam S, Zawadzki RJ, Choi S, Gerth C, Park SS, Morse L et al. Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging. Ophthalmology 2006; 113: 1425–1431.
Aizawa S, Mitamura Y, Baba T, Hagiwara A, Ogata K, Yamamoto S . Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. Eye 2009; 23: 304–308.
Fischer M, Fleischhauer JC, Gillies MC, Sutter FK, Helbig H, Barthelmes D . A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography. Invest Ophthalmol Vis Sci 2008; 49: 3617–3621.
Jacobson SG, Roman AJ, Aleman TS, Sumaroka A, Herrera W, Windsor EA et al. Normal central retinal function and structure preserved in retinitis pigmentosa. Invest Ophthalmol Vis Sci 2010; 51: 1079–1085.
Robson AG, Michaelides M, Saihan Z, Bird AC, Webster AR, Moore AT et al. Functional characteristics of patients with retinal dystrophy that manifest abnormal parafoveal annuli of high density fundus autofluorescence; a review and update. Doc Ophthalmol 2008; 116: 79–89.
Lupo S, Grenga PL, Vingolo EM . Fourier-domain optical coherence tomography and microperimetry findings in retinitis pigmentosa. Am J Ophthalmol 2011; 151: 106–111.
Lenassi E, Troeger E, Wilke R, Hawlina M . Correlation between macular morphology and sensitivity in patients with retinitis pigmentosa and hyperautofluorescent ring. Invest Ophthalmol Vis Sci 2012; 53: 47–52.
Curcio C, Messinger JD, Sloan KR, Mitra A, McGwin G, Spaide RF . Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections. Invest Ophthalmol Vis Sci 2011; 52: 3943–3954.
Dhoot DS, Huo S, Yuan A, Xu D, Srivistava S, Ehlers JP et al. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br J Ophthalmol 2013; 97: 66–69.
Mitamura Y, Aizawa S, Baba T, Hagiwara A, Yamamoto S . Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. Br J Ophthalmol 2009; 93: 126–127.
Acton JH, Greenstein VC . Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications. Can J Ophthalmol 2013; 48: 358–363.
Cideciyan A, Swider M, Aleman TS, Feuer WJ, Schwartz SB, Russell RC et al. Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials. Invest Ophthalmol Vis Sci 2012; 53: 841–852.
HGMD, Human Gene Mutation Database (Biobase BiologicalDatabases) 2013. Retrieved from http://www.hgmd.cf.ac.uk/. Accessed June 2014.
Retnet, The Retinal Information Network 2013. Retrieved from http://www.sph.uth.tmc.edu/RetNet/. Accessed June 2014. 2014.
Wert KJ, Lin JH, Tsang SH . General pathophysiology in retinal degeneration. Dev Ophthalmol 2014; 53: 33–43.
Issa PC, Troeger E, Finger R, Holz FG, Wilke R, Scholl HP . Structure-function correlation of the human central retina. PLoS One 2010; 5: e12864.
Itoh Y, Inoue M, Rii T, Hiraoka T, Hirakata A . Significant correlation between visual acuity and recovery of foveal cone microstructures after macular hole surgery. Am J Ophthalmol 2012; 153: 111–119.
Oishi A, Hata M, Shimozono M, Mandai M, Nishida A, Kurimoto Y . The significance of external limiting membrane status for visual acuity in age-related macular degeneration. Am J Ophthalmol 2010; 150: 27–32.
Itoh Y, Inoue M, Rii T, Hiraoka T, Hirakata A . Correlation between length of foveal cone outer segment tips line defect and visual acuity after macular hole closure. Ophthalmology 2012; 119: 1438–1446.
Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. Am J Ophthalmol 2012; 153: 698–704.
Srinivasan VJ, Monsoon BK, Wojtkowski M, Bilonick RA, Gorczynska I, Chen R et al. Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci 2008; 49: 1571–1579.
Battu R, Dabir S, Khanna A, Kumar AK, Roy AS . Adaptive optics imaging of the retina. Indian J Ophthalmol 2014; 62: 60–65.
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Battu, R., Khanna, A., Hegde, B. et al. Correlation of structure and function of the macula in patients with retinitis pigmentosa. Eye 29, 895–901 (2015). https://doi.org/10.1038/eye.2015.61
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DOI: https://doi.org/10.1038/eye.2015.61
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