Abstract
Purpose
To investigate the effect of 3% diquafosol sodium ophthalmic solution (DQS) on aqueous tear volume increase in dry-eye patients with Sjögren’s syndrome (SS).
Methods
In this pilot study, 17 dry-eye patients with SS (1 male and 16 females; mean age: 66.4 years) were enrolled and underwent topical instillation of two ophthalmic solutions, artificial tears (AT) in one eye and DQS in the fellow eye, in a masked manner. The central lower tear meniscus radius (TMR) curvature was measured before and at 15 min after instillation by video-meniscometry. Simultaneously, all patients self-evaluated their symptoms of wetness and stinging using a visual analog scale (VAS, in millimeters).
Results
Topical instillation of DQS significantly increased the TMR at 15 min (mean: 0.21±0.08 (SD) mm) compared with at baseline (mean: 0.16±0.07 mm) (P<0.001, paired t-test), whereas AT had no effect at baseline (mean: 0.18±0.09 mm) or at 15 min (mean: 0.18±0.09 mm). The visual VAS score of wetness at 15-min post-instillation increased in both groups compared with at baseline. In the DQS-treated eyes, the post-instillation change in TMR from baseline was not correlated with the baseline value of the Schirmer test, corneal staining score, or conjunctival staining score.
Conclusions
Topical instillation of DQS increased aqueous tear volume on the ocular surface of dry-eye patients with SS, with its action being independent of lacrimal gland function.
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Acknowledgements
We wish to thank Mr John Bush (Senior Editor, Kyoto Prefectural University of Medicine) for reviewing the manuscript. We make the following disclosures: Norihiko Yokoi: consultant for Kissei Co., Ltd., Nagano, Japan and Rohto Co., Ltd, Osaka, Japan. Shigeru Kinoshita: consultant for Santen Pharmaceutical Co., Ltd, Osaka, Japan and Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan. Hiroaki Kato has no relationship to disclose. This study was supported in part by Grants-in-Aid for scientific research from the Japanese Ministry of Education, Culture, Sports, Science and Technology. The authors have no proprietary or commercial interests in any of the materials discussed in this article.
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Yokoi, N., Kato, H. & Kinoshita, S. The increase of aqueous tear volume by diquafosol sodium in dry-eye patients with Sjögren’s syndrome: a pilot study. Eye 30, 857–864 (2016). https://doi.org/10.1038/eye.2016.54
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DOI: https://doi.org/10.1038/eye.2016.54
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