Abstract
Purpose: To describe genetic epidemiologic aspects of osteoporosis.
Methods: 69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures. Family history information was obtained on 421 first degree and 748 second degree relatives.
Results: 45% of cases reported a family history of osteoporosis. Familial cases were characterized neither by an earlier age of diagnosis nor by a greater degree of phenotypic severity. Empiric risks for osteoporosis were highest for mothers, 33%, and were 19% for sisters.
Conclusion: These results provide an initial genetic epidemiologic profile for osteoporosis and information useful for genetic counseling.
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Henderson, L., Adams, J., Goldstein, D. et al. A familial risk profile for osteoporosis. Genet Med 2, 222–225 (2000). https://doi.org/10.1097/00125817-200007000-00004
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DOI: https://doi.org/10.1097/00125817-200007000-00004
