Figure 1

NOTCH1 protein, position of truncating and RNA-splicing mutations. ↓Truncating and RNA-splicing mutations. ANK, ankyrin repeats; EGF, epidermal growth factor; HD, heterodimerization domain; LNR, Lin/Notch repeats; PEST, PEST domain; RAM, RBPjk-association module; TAD, transcriptional activation domain; TM, transmembrane domain.