Table 1 Paper selection criteria

From: Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature

Population

Studies in human health care

Intervention

Whole-genome and whole-exome sequencing (any platform)

Comparator

Other sequencing methods

 

Other diagnostic methods

 

No comparator

Outcomes

Costs

 

Clinically relevant outcome measures (diagnostic yield/successful diagnosis, time to diagnosis, change in treatment, survival rate, quality-adjusted life years)

Study designs

Health technology assessments, systematic reviews, meta-analyses, economic evaluations, evidence-based guidelines, conference abstracts, clinical trials

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