Table 3 Hematology and clinical chemistry of Ad5/3-cox2L-D24-treated patients

From: Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

Parameter

Pretreatment

Day 1

Day 4

2 weeks

3 weeks

4 weeks

Hemoglobin (g l−1)

110±14 (N= 18)

105±15 (N=18)

106±13 (N=10)

106±13 (N=10)

108±8 (N=10)

108±8 (N=9)

Erythrocytes (10e12 l−1)

3.6±0.5 (N=18)

3.4±0.5 (N=18)

3.7±0.5 (N=10)

3.6±0.5 (N=10)

3.52±0.4 (N=10)

3.7±0.2 (N=9)

Leukocytes (10e9 l−1)

5.3±2.5 (N=18)

4.9±2.5 (N=18)

4.7±1.6 (N=10)

6.4±2.4 (N=10)

6.5±3.0 (N=10)

6.8±3.5 (N=9)

Creatinine (μmol l−1)

63.1±14.9 (N=18)

58.7±13.4 (N=17)

66.7±12.8 (N=9)

67.7±21.2 (N=11)

48.6±11.0 (N=8)

65.5±21.8 (N=8)

INR

1.1±0.3(N=18)

1.1±0.2 (N=17)

1.1±0.3 (N=9)

1.2±0.5 (N=10)

1.2±0.3 (N=8)

1.1±0.1 (N=7)

K(mmol l−1)

3.9±0.5 (N=17)

4.0±0.3 (N=18)

3.8±0.3 (N=9)

4.1±0.3 (N=11)

4.3±0.8 (N=8)

3.8±0.3 (N=8)

Na(mmol l−1)

137±5 (N=17)

137±4 (N=18)

136±4 (N=9)

135±5 (N=11)

137±5 (N=9)

137±3 (N=7)

  1. Abbreviation: INR, international normalized ratio for blood clotting.
  2. All values are mean±s.d. Reference values (females/males/children); hemoglogin: 117–155/134–167/110–139; erythrocytes: 3.9–5.2/4.25–5.7/3.8–5.5; Leukocytes; adults 3.4–8.2, children 5–14; creatinine: <90/<100/<60; INR: adults 0.8–1.2, children 0.7–1.2; K: adults 3.7–5.3, children 3.3–5.2; Na: all 137–145.
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