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The chemical breakage of chromosomes
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  • Original Article
  • Published: 01 October 1947

The chemical breakage of chromosomes

  • C D Darlington1 &
  • P C Koller2 

Heredity volume 1, pages 187–221 (1947)Cite this article

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  • 116 Citations

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References

  • Auerbach, C. 1943. D. melanogaster: New mutants. Chemically induced mutations and rearrangements. Dros, Inform, Service, No 17, 48–50.

  • Auerbach, C. 1945. The problem of chromosome rearrangements in somatic cells of D. melanogaster. PRS Edin, B, 62, 120–127.

    Google Scholar 

  • Auerbach, C. 1946. Chemically induced mosaicism in D. melanogaster. PRS Edin, B, 62, 211–222.

    CAS  Google Scholar 

  • Auerbach, C. 1947. Abnormal segregation after chemical treatment of Drosophila. Genetics, 32, 3–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Auerbach, C, et al. 1943. Ministry Supply Report.

  • Auerbach, C, and Robson, J M. 1944. Mutation chemically induced. Product of mutations by allyl isothio-cyanite. Nature (Lond.), 154, 81.

    Article  CAS  Google Scholar 

  • Auerbach, C, Robson, J M, and Carr, J G. 1947. The chemical production of mutations. Science, 105, 243–247.

    Article  CAS  Google Scholar 

  • Barber, H N. 1942. The experimental control of chromosome pairing in Fritillaria. J Genet, 43, 359–374.

    Article  Google Scholar 

  • Beadle, G W. 1932. A gene for sticky chromosomes in Zea mays. ZIAV, 63, 195–217.

    Google Scholar 

  • Berenblum, I, et al. 1936. Tumour metabolism in the presence of anti-carcinogenic substances. Biochem J, 30, 709–715.

    Article  CAS  Google Scholar 

  • Cashmore, A E, and McCombie, H. 1923. The interaction of β, β′ -dichlorodiethyl sulphide, sulphoxide and sulphur with glycine ester and with potassium phthalamide. J Chem Soc, 2884–2890.

  • Chevais, J, and Thomas, J A. 1943. Variation du taux de mutations provoquées par l'aminophénylsulphamide chez la Drosophile suivant le délai compris entre le traitement du maie et le croisement. CR Soc Biol, 137, 187–189.

    CAS  Google Scholar 

  • Dale, W M. 1942. The effect of X-rays on the conjugated protein d-amino-acid oxidase. Biochem J, 36, 80–85.

    Article  CAS  Google Scholar 

  • Darlington, C D. 1937. Recent Advances in Cytology. 2nd ed. London.

  • Darlington, C D. 1939. Misdivision and the genetics of the centromere. J Genet, 37, 341–364.

    Article  Google Scholar 

  • Darlington, C D. 1940. The prime variables of meiosis. Biol Rev, 75, 307–322.

    Article  Google Scholar 

  • Darlington, C D. 1942. Chromosome chemistry and gene action. Nature (Lond.), 149, 66–69.

    Article  CAS  Google Scholar 

  • Darlington, C D. 1944. Heredity, development and infection. Nature (Lond.), 154, 164–169.

    Article  CAS  Google Scholar 

  • Darlington, C D. 1947. Nucleic acid and the chromosomes. Symp Soc exp Biol 1. Nucleic Acid, 252–269.

    Google Scholar 

  • Darlington, C D, and La Cour, L F. 1945. Chromosome breakage and the nucleic acid cycle. J Genet, 46, 180–267.

    Article  Google Scholar 

  • Darlington, C D, and La Cour, L F. 1947. The Handling of Chromosomes. 2nd ed. London.

  • Darlington, C D, and Upcott, M B. 1941. Spontaneous chromosome change. J Genet, 41, 297–338.

    Article  Google Scholar 

  • Gilman, A, and Philips, F S. 1946. The biological actions and therapeutic applications of the β-chloroethyl amines and sulphides. Science, 103, 409–415.

    Article  CAS  Google Scholar 

  • Hadorn, E, and Niggli, H. 1946. Mutations in Drosophila after chemical treatment of gonads in vitro. Nature (Lond.), 157, 162–163.

    Article  CAS  Google Scholar 

  • Haddow, A. 1944. Transformation of cells and viruses. Nature (Lond.), 154, 194–199.

    Article  Google Scholar 

  • Hartwell, J L. 1946. Reactions of bis (2-chloroethyl) sulphide and some of its derivatives with proteins and amino acids. J Nat Cancer Inst, 6, 319–324.

    CAS  PubMed  Google Scholar 

  • Hevesy, G. 1946. Effect of X-rays on the rate of turnover of phosphatides. Nature (Lond.), 158, 268.

    Article  CAS  Google Scholar 

  • Hollaender, A. 1946. Effects of ultraviolet radiation. Ann Rev Physiol, 8, 1–16.

    Article  CAS  Google Scholar 

  • Horowitz, N H, et al. 1946. Mustard gas mutations in Neurospora. Science, 104, 233–234.

    Article  CAS  Google Scholar 

  • Koller, P C. 1938. Asynapsis in Pisum sativum. J Genet, 36, 275–306.

    Article  Google Scholar 

  • Koller, P C. 1943. The effects of radiation on pollen grain development, differentiation and germination. PRS Edin, B, 61, 398–429.

    Google Scholar 

  • Koller, P C. 1946. The response of Tradescantia pollen grains to radiation at different dosage-rates. Brit J Radiol, 19, 393–404.

    Article  CAS  Google Scholar 

  • Koller, P C. 1947a. Experimental modification of nucleic acid systems in the cell. Symp Soc exp Biol 1. Nucleic Acid, 270–290.

    Google Scholar 

  • Koller, P C. 1947b. Abnormal mitosis in tumours. Brit J Cancer 1, 38–47.

    Article  CAS  Google Scholar 

  • La Cour, L F. 1946. John Innes Hort Inst 36th Ann Report, 1945.

  • Latarjet, R. 1946. L'effet biologique primaire des radiations et la structure des microorganismes. Rev Canad de Biologie, 5, 9–47.

    CAS  Google Scholar 

  • Lea, D E. 1946. Actions of Radiations on Living Cells. Cambridge.

  • Macrenzie, R, and Muller, H J. 1940. Mutation effects of ultra-violet light in Drosophila. PRS, B, 129, 491–517.

    Google Scholar 

  • McAulay, A L, and Ford, J M. 1947. Saltant production in the fungus ChÅ“tomium globosum by ultra-violet light, etc. Heredity, 1, 247–257.

    Article  Google Scholar 

  • McClintock, B. 1942. The fusion of broken ends of chromosomes following nuclear fusion. PNAS, 28, 458–463.

    Article  CAS  Google Scholar 

  • Mather, R. 1934. The behaviour of meiotic chromosomes after X-irradiation. Hereditas, 19, 303–322.

    Article  Google Scholar 

  • Mitchell, J S. 1943. Metabolic effects of therapeutic doses of X and gamma radiations. Brit J Radiol, 16, 339–343.

    Article  CAS  Google Scholar 

  • Muller, H J. 1940. An analysis of the process of structural change in chromosomes of Drosophila. J Genet, 40, 1–66.

    Article  Google Scholar 

  • Oehlkers, F. 1943. Die Auslösung von Ghromosomeii-mutationen in der Meiosis durch Einwirkung von Chemikalien. ZIAV, 81, 313–341.

    Google Scholar 

  • Van Potter, R. 1945. The genetic aspects of the enzyme-virus theory of cancer. Science, 101, 609–610.

    Article  Google Scholar 

  • Sax, K. 1938. Chromosome aberrations induced by X-rays. Genetics, 23, 494–516.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sax, K. 1939. The time factor in X-ray production of chromosome aberrations. PNAS, 25, 225–233.

    Article  CAS  Google Scholar 

  • Sax, K. 1941. Types and frequencies of chromosomal aberrations induced by X-rays. Cold Spr Harb Symp, 9, 93–103.

    Article  Google Scholar 

  • Sax, K. 1942. The mechanisms of X-ray effects on cells. J gen Physiol, 25, 533–537.

    Article  CAS  Google Scholar 

  • Slizynski, B M. 1943. D. melanogaster. Stock Lists. British Isles. Dros Inform Service, No. 17, 43.

  • Stadler, L J. 1941. The comparison of ultra-violet and X-ray effects on mutation. Cold Spr Harb Symp, 9, 168–177.

    Article  Google Scholar 

  • Strong, L C. 1945. Germinal mutations and other sudden biological changes following the subcutaneous injection of methylcholanthrene. PNAS, 31, 290–293.

    Article  CAS  Google Scholar 

  • Stubbe, H. 1940. Neue Forschungen zur experimentellen Erzeugung von Mutationen. Biol Zbl, 60, 113–129.

    CAS  Google Scholar 

  • Woods, W M, and Dubuy, H G. 1945. Cytoplasmic diseases and cancer. Science, 102, 591–593.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. John Innes Horticultural Institution, Merton

    C D Darlington

  2. Chester Beatty Research Institute, Royal Cancer Hospital, Fulham Road, London

    P C Koller

Authors
  1. C D Darlington
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  2. P C Koller
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Darlington, C., Koller, P. The chemical breakage of chromosomes. Heredity 1, 187–221 (1947). https://doi.org/10.1038/hdy.1947.13

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  • Issue date: 01 October 1947

  • DOI: https://doi.org/10.1038/hdy.1947.13

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