Abstract
An examination of the chiasma distribution in chromosome 1 of male mice homozygous and heterozygous for a distal inversion In(1) 12Rk and in normal males was carried out. No differences in chiasma distribution were found between homozygotes for the inversion and homozygotes for normal chromosome 1. A significant decrease in the frequency of bivalents bearing chiasmata in the pretelomeric region was found in heterozygotes. This, in its turn, produced a redistribution of chiasmata in the proximal non-inverted part of bivalent 1. These results could be interpreted as evidence for positional control of the chiasma distribution pattern: the distance of certain parts of the chromosome from the telomere and chiasmata interference are more important for determination of the chiasma frequency in a given region than its genetic content.
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We are extremely grateful to Dr L. V. Vysotskaya and Dr B. F. Chadov for their helpful comments on the manuscript, and to Mrs Marina I. Rodionova for technical assistance.
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Gorlov, I., Ladygina, T., Serov, O. et al. Positional control of chiasma distribution in the house mouse. Chiasma distribution in mice homozygous and heterozygous for an inversion in chromosome 1. Heredity 66, 453–458 (1991). https://doi.org/10.1038/hdy.1991.55
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DOI: https://doi.org/10.1038/hdy.1991.55
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