Table 1 Neurospora’s heterochromatin machinery
From: DNA methylation and the formation of heterochromatin in Neurospora crassa
Protein | Domain(s) | Mutant phenotype | Principal activity |
|---|---|---|---|
RID | DMT | RIP defect | DMT and/or deaminase in ascogenous cells |
DIM-5 | HMT | No H3K9me3; no 5mCa | Trimethylation of H3K9 |
HP1 | Chromo and Chromo-shadow | No 5mC | Adapter protein that binds H3K9me3 and recruits DIM-2 and DMM-1 |
DIM-2 | DMT and 2 PXVXL-related | No 5mC | 5mC in vegetative cells |
DMM-1 | JmjC; Cys-rich and 3 A:T-hooks | 5mC patterns altered | ? |
DMM-2 | Zn(II)2Cys6 | 5mC patterns altered | ? |
PP1 | Serine/threonine phosphatase | H3K9me3 and 5mC deficits | H3S10p phosphatase |
