Table 1 Potential forms of selection on mutation rate modifiers discussed in this review
From: Experimental evolution and the dynamics of genomic mutation rate modifiers
Source of selection | Type of selection | Strength | Outcome |
|---|---|---|---|
Hitchhiking with beneficial mutations | Indirect | Strong, immediate | Favors higher rate |
Increased load of deleterious mutations | Indirect | Weak, delayed | Favors lower rate |
Cost of genomic replication fidelity | Direct | Weak | Favors higher rate |
Pleiotropic fitness effects of modifiers | Direct | Largely unknown | Unknown |
