Table 5 Criteria for quality assessment of genetic association of ApoE ɛ2/ɛ3/ɛ4 polymorphism with hypertension

From: The relationship between apolipoprotein E ɛ2/ɛ3/ɛ4 polymorphisms and hypertension: a meta-analysis of six studies comprising 1812 cases and 1762 controls

Criteria

Quality score

Representativeness of cases

 A. Consecutive/randomly selected from case population with clearly defined random frame

2

 B. Consecutive/randomly selected from case population without clearly defined random frame or with extensive inclusion criteria

1

 C. Method of selection not described

0

Representativeness of controls

 D. Controls were consecutive/randomly drawn from the same area (ward/community) as cases with the same criteria

2

 E. Controls were consecutive/randomly drawn from a different area than cases

1

 F. Not described

0

Ascertainment of hypertension cases

 G. Clearly described objective criteria for diagnosis of hypertension

1

 H. Not described

0

Ascertainment of controls

 I. Clinical examinations were performed on controls to prove that controls did not have hypertension

2

 J. Article merely stated that controls were subjects who did not have hypertension; no proof provided

1

 K. Not described

0

Ascertainment of genotyping examination

 L. Genotyping done under “blind” conditions

1

 M. Unblended or not mentioned

0

Test for Hardy–Weinberg equilibrium

 N. Hardy–Weinberg equilibrium in control group

2

 O. Hardy–Weinberg disequilibrium in control group

1

 P. Hardy–Weinberg equilibrium not checked

0

Association assessment

 Q. Assessed association between genotypes and hypertension with appropriate statistic and adjusting confounders

2

 R. Assessed association between genotypes and hypertension with appropriate statistic without adjusting confounders

1

 S. Inappropriate statistic used

0

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