Figure 3
From: Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats
Western blot analysis of endothelial nitric oxide synthase (eNOS) and biopterin production. (a) Total eNOS was examined by normal SDS–PAGE. (b) Dimer/monomer eNOS were examined by low temperature SDS–PAGE. n=6 in each group. *P<0.05 vs. DS-L (DS normotensive rats fed a 0.9% salt diet), †P<0.05 vs. DS-H-Hyd (DS rats treated with hydralazine). (c) Real-time PCR for guanosine-5′-triphosphate cyclohydrolase 1 (GTPCH1) mRNA expression. n=5 in each group. *P<0.05 vs. DS-L. (d) Serum tetrahydrobiopterin (BH4) concentration. (e) Dihydrobiopterin (BH2) concentration. n=5 in each group. *P<0.05 vs. DS-L, †P<0.05 vs. DS-H-Hyd. DS, Dahl salt-sensitive hypertensive.
