Table 1 Pathophysiological data

From: Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats

 

DS-L

DS-H

DS-H-Hyd

DS-H-Tel

Physiological data (n=15)

Body weight (g)

433±10

386±7*

402±9

402±8

Systolic blood pressure (mm Hg)

114±2

190±3*

136±3**

134±3**

Serum creatinine (mg 100 ml−1)

0.27±0.01

0.37±0.02*

0.35±0.02

0.38±0.02

Blood urea nitrogen (mg 100 ml−1)

18.9±1.0

24.2±1.3*

22.9±1.8

22.3±1.1

Urinary protein excretion (mg per day)

27.0±2.9

106.4±6.9*

70.7±5.7**

52.1±3.3**,***

Histology (n=5)

Glomerular damage (score 0–4)

0.18±0.02

1.35±0.14*

1.10±0.06**

0.79±0.08**,***

  1. Abbreviations: DS-H, untreated DS rats; DS-H-Hyd, DS rats treated with hydralazine; DS-L, DS normotensive rats fed a 0.9% salt diet; DS-H-Tel, DS rats treated with telmisartan.
  2. Data are expressed as mean±s.e.m.
  3. P<0.05 vs. DS-L.
  4. P<0.05 vs. DS-H.
  5. P<0.05 vs. DS-H-Hyd.
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