Table 4 The effect of tumor removal in the subset of patients with pheochromocytoma compared with control subjects

From: Factors influencing arterial stiffness in pheochromocytoma and effect of adrenalectomy

 

Pheochromocytoma

 

Before surgery

After surgery

P (paired data)

Controls

Sex (female/male)

27 (13/14)

27 (13/14)

—

45 (20/25)

Age (years)

45±12

46±12

<0.001

44±10

Body mass index (kg m−2)

25±4

26±4

<0.001

25±4

Total cholesterol (mmol l–1)

5.4±0.9

4.7±1.1

0.003

5.2±1.0

Triglycerides (mmol l–1)

1.6±1.2

1.3±0.4

0.117

1.4±0.9

Fast.plasma glucose (mmol l–1)

6.0±1.7aaa

4.7±0.6

<0.001

4.8±0.5

hs-CRP (mg l–1)

0.50 (0.27;1.00)

0.19 (0.12;0.57)

0.040

NA

24 h urine epinephrineb

593 (34;1766)aaa

14 (9;21)

<0.001

25 (13;35)

24 h urine norepinephrineb

1426 (588;3501)aaa

139 (113;199)

<0.001

118 (94;162)

Heart rate (b.p.m.)

71±15a

65±9

0.017

66±10

Brachial BP (mm Hg)

134±18/77±11aaa/aa

117±13/71±8

<0.001/ 0.003

117±11/70±8

Central BP (mm Hg)

119±17/78±12aaa/aa

106±12/72±9

<0.001/ 0.003

104±10/71±8

Mean 24 h BP (mm Hg)

127±16/78±12a/−

115±7/73±6

<0.001/0.04

116±9/73±7

Daytime BP variation (mm Hg)

12±4/10±2a/−

10±3/9±2

0.036/0.07

10±3/9±2

AI 75 (%)c

19±13

18±13

0.560

14±13

Pulse wave velocity (ms−1)

7.0±1.2aaa

6.0±1.1

< 0.001

5.8±0.5

PWVadj (ms−1)d

6.7±0.2aa

6.0±0.1

<0.01

6.0±0.1

  1. Abbreviations: AI, augmentation index; BP, blood pressure; hs-CRP, high-sensitive C-reactive protein.
  2. Values are means±s.d. or medians (interquartile range).
  3. P<0.05, aaP<0.01, aaaP<0.001 baseline PHEO vs. C.
  4. bnmol g–1 creatinine.
  5. cAugmentation index for heart rate 75 beats per min.
  6. dAdjusted for age, heart rate, brachial mean blood pressure and fasting plasma glucose.
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