Figure 1

Quadratic curves representing the mean and 5th, 10th, 90th and 95th percentiles of the plasma levels of sFlt-1 (a) and PlGF (b) and the sFlt-1/PlGF ratio (c) from 20 to 38 weeks of gestation. Solid curves represent the 5th and 95th percentiles of the reference values, dashed curves represent the 10th and 90th percentiles, and the dotted curve represents the mean. Small closed circles represent the values in the 144 normal controls. Large closed circles represent the values in the 15 women with early-onset (EO) preeclampsia (PE); large open circles represent the values in the 13 women with late-onset (LO) PE complicated with preterm delivery and medium-sized open circles represent the values in the 6 women with LO-PE with term delivery.