Figure 1 | Hypertension Research

Figure 1

From: Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models

Figure 1

Schematic representation of the first set of newly developed congenic substrains. Congenic substrains were developed from S.SHR(9)x8A as described under Methods. The physical map of rat chromosome 9 is shown on the left with locations of markers in base pairs shown within parenthesis. Newly developed polymorphic microsatellite markers are given D9Mco numbers. Markers that begin with RNO9 are single-nucleotide polymorphic markers. RNO9 (SDPR-Exon 2) is a C/T single-nucleotide polymorphism between S and SHR. *The S.SHR(9)x8A congenic strain was previously reported and is shown here for reference. The solid bars represent SHR introgressed segments of the congenic strains. Open boxes flanking the solid bars are where recombinations occurred. The blood pressure (BP) data obtained from these congenic substrains are provided in Table 1. Black bars indicate congenic strains with BP significantly lower than that of the S. Gray bars indicate congenic strains with no BP effect.

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